1242283-05-1Relevant academic research and scientific papers
Aza-Michael addition reactions of hydrazones with activated alkynes catalyzed by nitrogen-containing organic bases
Yuan, Zhi-Liang,Wei, Yin,Shi, Min
supporting information; experimental part, p. 4088 - 4097 (2010/10/02)
Several highly efficient DABCO (1, 4-diazabicyclo[2.2.2]octane)-catalyzed Michael-type reactions of hydrazones with activated alkynes are described in this paper. This azaMichael addition reaction can be applied to different types of hydrazones, such as hydrazones 1 and hydroxy-bearing hydrazones 5. The corresponding adducts are achieved in high yields under mild reaction conditions. DABCO-promoted aza-Michael addition reactions were successfully applied to a serious of hydrazones with activated alkynes to afford the corresponding adducts in moderate to good yields.
