1242316-87-5

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 99-02-5 3'-Chloroacetophenone 
• 3724-43-4 Vilsmeier reagent 

Downstream Products

• 1219452-61-5 (Z)-methyl 5-chloro-5-(3-chlorophenyl)-3-hydroxy-2-methylenepent-4-enoate 
• 1254255-22-5 (Z)-methyl 5-chloro-5-(3-chlorophenyl)-2-methylene-3-(phenylsulfonamido)pent-4-enoate 
• 1254255-21-4 (Z)-methyl 5-chloro-5-(3-chlorophenyl)-2-methylene-3-(4-tolylsulfonamido)pent-4-enoate 
• 1361123-91-2 3-((2E,4Z)-5-chloro-5-(3-chlorophenyl)-2-(methoxycarbonyl)penta-2,4-dienyl)-1-methyl-1H-imidazol-3-iumhydrogensulfate 
• 1361123-99-0 (2E,4Z)-ethyl-5-chloro-5-(3-chlorophenyl)-2-(nitrooxymethyl)penta-2,4-dienoate 
• 1219452-62-6 C₁₄H₁₄Cl₂O₃ 
• 1374843-02-3 (2E,4Z)-1-(3-bromo-2-hydroxy-4,6-dimethoxyphenyl)-5-chloro-5-(3-chloro phenyl)penta-2,4-dien-1-one 

Relevant academic research and scientific papers

Unexpected tandem reaction of new type moritabaylis- Hillman adducts promoted by [HMIM]HSO4/NANO3 system

A tandem reaction of new type Baylis-Hillman adducts 1 was prompted by ionic liquid [Hmim]HSO4/NaNO3 system and the unexpected products 6-aryl-2H-pyran-3-carboxylates 2 and imidazolium salts 3 were efficiently formed via the rearrang

Synthesis, biological evaluation and in silico study of β-chloro vinyl chalcones as inhibitors of the TNF-α, IL-6 with anticancer and antioxidant activity

A series of novel β-chloro vinyl chalcones have been synthesized from substituted (Z)-3-chloro-3-phenylacraldehydes with 1-(3-bromo-2-hydroxyl-4,6- dimethoxyphenyl)ethanone by Claisen-Schmidt condensation reaction. Compounds were screened for anti-inflammatory, anticancer and antioxidant activity. Compounds 6a, 6d and 6f revealed promising anti-inflammatory activity (87-99 %) with less cytotoxicity (4-9 %) at 10 μM. Compounds 6a, 6d, 6e and 6f having significant anticancer activity (71-83 %). Bioavailability of compounds were checked by in vitro cytotoxicity and confirmed to be nontoxic. Structure activity relationship and in silico drug relevant properties of compounds revealed as potential candidates for future drug discovery study.

Efficient synthesis of a new type of baylis-hillman adducts and their stereoselective bromination

A new type of Baylis-Hillman adducts derived from chlorovinyl aldehydes were prepared via Vilsmeier reaction of ketones with a bis(trichloromethyl) carbonate (BTC)/DMF system to construct chlorovinyl aldehydes, followed by sonochemical Baylis-Hillman reaction under solvent-free conditions. The stereoselective bromination of these new compounds with a Br2-Ph3P system has been achieved efficiently with good to excellent yields under mild conditions. Copyright Taylor & Francis Group, LLC.

One-pot synthesis of new type aza- Baylis-Hillman adducts from chlorovinyl aldehydes under solvent-free condition

A series of new type aza- Baylis-Hillman adducts were prepared in moderate yields by one-pot treatment of chlorovinyl aldehydes, benzenesulfonamides and activated olefi ns under solvent-free condition. The chlorovinyl aldehydes were obtained via chlorofor