1242430-23-4

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 
• 106-40-1 4-bromo-aniline 

Relevant academic research and scientific papers

Synthesis of tetrahydropyridines by one-pot multicomponent reaction using nano-sphere silica sulfuric acid

A highly efficient protocol for the synthesis of 1,2,3,4-tetrahydropyridines in the presence of nano-sphere silica sulfuric acid (NS-SSA) was used for good yields by one-pot multicomponent reaction (MCRs). The reagent nano-sphere silica sulfuric acid (NS-SSA) has several advantages, such as easy workup, nontoxicity, convenience and high yields of products.

Kinetics and mechanism investigation of the synthesized highly diasteroselective substituted tetrahydropyridines in the presence of La(NO3)3·6H2O as a catalyst

For the first time, kinetics and mechanism of reaction between 4-methyl-benzaldehyde, 4-bromoaniline and methyl acetoacetate is spectrally investigated in the presence of La(NO3)3·6H2O as a catalyst. Based on the experimen

Fe(NO3)3·9H2O as efficient catalyst for one-pot synthesis of highly functionalized piperidines

Fe(NO3)3·9H2O is used as an efficient and effective catalyst for the one-pot three-component synthesis of highly functionalized piperidines from aromatic aldehydes, anilines and β-ketoesters in ethanol at ambient temperature. This procedure includes some important aspects like the easy work-up, no need to column chromatography, simple and readily available precursors, and good to high yields.

Al(H2PO4)3 as an efficient and reusable catalyst for the multi-component synthesis of highly functionalized piperidines and dihydro-2-oxypyrroles

Extremely facile and efficient procedures have been developed for the synthesis of highly functionalized piperidines and dihydro-2-oxypyrroles via one-pot multi-component reactions in the presence of Al(H2PO 4)3 as a heterogeneous and eco-friendly catalyst under mild conditions. The multi-component reaction of aromatic aldehydes, aromatic amines, and β-keto esters catalyzed by Al(H2PO4) 3 in EtOH at room temperature provides highly functionalized piperidines in good to excellent yields. The structure as well as the relative stereochemistry of these functionalized piperidines was confirmed by single X-ray crystallographic analysis. The same catalyst was found useful for the synthesis of polyfuntionalized dihydro-2-oxypyrroles using a four-component reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in MeOH at ambient temperature. It is found that the catalyst is recyclable and can be used up to five times without significant loss of its activity.

One-pot five-component synthesis of highly functionalized piperidines using oxalic acid dihydrate as a homogenous catalyst

An efficient green protocol is described for the preparation of highly functionalized piperidines via a one-pot five-component reaction between aromatic aldehydes, anilines and β-ketoesters in the presence of oxalic acid dihydrate as catalyst in ethanol at ambient temperature. The structure as well as the relative stereochemistry of these compounds was confirmed by single X-ray crystallographic analysis.

Cerium ammonium nitrate-catalyzed multicomponent reaction for efficient synthesis of functionalized tetrahydropyridines

A highly atom-economic one-pot synthesis of functionalized tetrahydropyridines by a multicomponent condensation reaction of β-keto ester, two equivalents of aromatic aldehyde, and two equivalents of amine in the presence of a catalytic amount of cerium ammonium nitrate (CAN) is reported. In this way, a series of pharmacologically interesting substituted piperidine derivatives were obtained in moderate to good yields at room temperature.