1242441-48-0

Basic information

• Product Name: (1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate
• Synonyms: (1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate
• CAS NO: 1242441-48-0
• Molecular Weight: 399.901
• Mol File: 1242441-48-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate(1242441-48-0)
• EPA Substance Registry System: (1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate(1242441-48-0)

Safety Data

• Hazardous Substances Data: 1242441-48-0(Hazardous Substances Data)

Usage

General Description

"(1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate" is a complex chemical compound that belongs to the class of cyclopropane carboxylates. It contains a cyclopropane ring and a variety of functional groups, including an ethyl ester, a phenyl group, a thioimidazole, and a chloropyridine. (1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate likely has various applications in the fields of chemistry, biology, and medicine due to its unique structure and potential reactivity. However, further research and experimentation are needed to fully understand its properties and potential uses.

Upstream product

• 16110-09-1 2,5 dichloropyridine 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 1242440-99-8 (1S,2S)-ethyl 2-(4-(1-trityl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate 
• 40771-41-3 2-mercapto-5-chloro-pyridine 
• 1242440-98-7 (1S,2S)-ethyl 2-(4-(1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate 
• 875479-34-8 ethyl trans-2-(4-bromophenyl)cyclopropane-1-carboxylate 
• 1319211-95-4 (1S,2S)-ethyl 2-(4-(5-iodo-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate 

Downstream Products

• 1242441-49-1 (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid 
• 1242441-56-0 [³H]-(1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)-N,Ndimethylcyclopropanecarboxamide 
• 1242441-47-9 (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)-N,Ndimethylcyclopropanecarboxamide 

Relevant articles and documents

Discovery of MK-3168: A PET tracer for imaging brain fatty acid amide hydrolase

We report herein the discovery of a fatty acid amide hydrolase (FAAH) positron emission tomography (PET) tracer. Starting from a pyrazole lead, medicinal chemistry efforts directed toward reducing lipophilicity led to the synthesis of a series of imidazole analogues. Compound 6 was chosen for further profiling due to its appropriate physical chemical properties and excellent FAAH inhibition potency across species. [11C]-6 (MK-3168) exhibited good brain uptake and FAAH-specific signal in rhesus monkeys and is a suitable PET tracer for imaging FAAH in the brain.