124246-69-1Relevant academic research and scientific papers
A fluorescence-based assay for high-throughput screening of coupling reactions. Application to heck chemistry
Shaughnessy, Kevin H.,Kim, Paul,Hartwig, John F.
, p. 2123 - 2132 (1999)
A new fluorescence-based assay for high-throughput screening of reactions that couple two organic molecules is described. The assay involves reaction of one substrate containing a tethered fluorophore with a second molecule that is attached to a solid sup
Cytocompatible, Photoreversible, and Self-Healing Hydrogels for Regulating Bone Marrow Stromal Cell Differentiation
Yu, Lianlian,Xu, Kaige,Ge, Liangpeng,Wan, Wenbing,Darabi, Ali,Xing, Malcolm,Zhong, Wen
, p. 1381 - 1390 (2016)
Photo-crosslinking and self-healing have received considerable attention for the design of intelligent materials. A novel photostimulated, self-healing, and cytocompatible hydrogel system is reported. A coumarin methacrylate crosslinker is synthesized to modify the polyacrylamide-based hydrogels. With the [2+2] cyclo-addition of coumarin moieties, the hydrogels exhibit excellent self-healing capacity when they are exposed to light with wavelengths at 280 and 365 nm, respectively. To enhance cell compatibility, a poly (amidoamine) crosslinker is also synthesized. Variations in light exposure times and irradiation wavelengths are found to alter the self-healing property of the hydrogels. The hydrogels are shown to induce a regular cellular pattern. The hydrogels are used to regulate bone marrow stromal cells differentiation. The relative mRNA expressions are recorded to monitor the osteogenic differentiation of the cells. (Figure presented.).
Coumarin derivative and preparation method thereof, and hydrogel prepared from coumarin derivative
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Paragraph 0028; 0047; 0048, (2017/02/17)
The invention provides a coumarin derivative with a structure as shown in a formula (I) which is described in the specification. The invention also provides a preparation method for the coumarin derivative and a hydrogel including the coumarin derivative as polymerization monomer. Through structural modification of the coumarin derivative provided by the invention, the coumarin derivative can be conveniently introduced into the copolymerization structure of the hydrogel and has good reaction activity; the introduction amount of a group can be controlled; and as the coumarin derivative and other modifiers are introduced into the hydrogel, no adverse influence is produced, and the coumarin derivative and the modifiers have good reaction activity and cooperatively act to improve the properties of the hydrogel. The preparation method for the coumarin derivative is simple in process and low in cost. Due to introduction of the coumarin derivative, the hydrogel provided by the invention has excellent self-repairing performance and improved biocompatibility; thus, the hydrogel is widely applicable as a self-repairing material with biocompatibility.
