1242516-34-2Relevant academic research and scientific papers
Lewis acid catalyzed highly stereoselective domino-ring-opening cyclization of activated aziridines with enolates: Synthesis of functionalized chiral γ-lactams
Ghorai, Manas K.,Tiwari, Deo Prakash
supporting information; experimental part, p. 6173 - 6181 (2010/11/05)
Figure presented. A highly enantio- and diastereoselective Lewis acid catalyzed SN2-type ring opening followed by cyclization of aziridines with active methylene carbon nucleophiles to functionalized chiral γ-lactams in a domino fashion has been developed. γ-Lactams have been desulfonated and decarboxylated, providing pyrrolidone-3-carboxylate and N-tosylpyrrolidinone derivatives, respectively, in good yields.
