1242597-71-2Relevant academic research and scientific papers
Total syntheses of arylindolizidine alkaloids (+)-ipalbidine and (+)-antofine
Niphakis, Micah J.,Georg, Gunda I.
, p. 6019 - 6022 (2010)
This paper presents the first application of two recently developed reactions to natural product synthesis. The first method involves a 6-endo-trig cyclization to prepare a versatile chiral enaminone building block. The second is a direct C-H arylation reaction. As a showcase for the utility of these methods, (+)-antofine and (+)-ipalbidine were synthesized in only 8 steps and 24-26% overall yields.
