1242597-75-6

Upstream product

• 1242597-66-5 (S)-6-(4-methoxyphenyl)-2,3,8,8a-tetrahydroindolizin-7(1H)-one 
• 1301743-55-4 (6R,7S,8aS)-hexahydro-7-hydroxy-6-(4-methoxyphenyl)indolizin-3(5H)-one 
• 1301743-50-9 methyl 3-((2R,4S,5S)-4-hydroxy-5-(4-methoxyphenyl)-N-hydroxypiperidin-2-yl)propanoate 
• 1301743-49-6 (3R,4S)-4-hydroxy-6-(3-methoxy-3-oxopropyl)-3-(4-methoxyphenyl)-2,3,4,5-tetrahydropyridine-1-oxide 
• 1301743-48-5 (6S,7R)-methyl 6-hydroxy-7-(4-methoxyphenyl)-8-nitro-4-oxooctanoate 
• 1301743-54-3 methyl 3-(2-((2S, 3R)-2-hydroxy-3-(4-methoxyphenyl)-4-nitrobutyl)-1,3-dioxolan-2-yl)propanoate 
• 1301743-51-0 (6R,7S,8aS)-octahydro-6-(4-methoxyphenyl)indolizin-7-ol 

Downstream Products

• 1242597-68-7 (6R,7S,8aS)-octahydro-6-(4-methoxyphenyl)-7-methylindolizin-7-ol 
• 1242597-71-2 (S)-6-(4-methoxyphenyl)-1,2,3,5,8,8a-hexahydroindolizin-7-yl trifluoromethanesulfonate 
• 104069-35-4 (8aS)-6-(4-methoxyphenyl)-7-methyl-1,2,3,5,8,8a-hexahydroindolizine 
• 23506-90-3 4-[(8aS)-7-methyl-1,2,3,5,8,8a-hexahydroindolizin-6-yl]phenol 

Relevant academic research and scientific papers

A simple enantioselective route to functionalized indolizidines: Synthesis of (+)-ipalbidine and (+)-antofine

An efficient route to functionalized indolizidines from an enantiomerically enriched γ-nitro ketone is described. The nitro ketone is obtained by an organocatalytic, enantioselective ketone-nitro alkene Michael addition. Oxidative ring expansion of the ni

Total syntheses of arylindolizidine alkaloids (+)-ipalbidine and (+)-antofine

This paper presents the first application of two recently developed reactions to natural product synthesis. The first method involves a 6-endo-trig cyclization to prepare a versatile chiral enaminone building block. The second is a direct C-H arylation reaction. As a showcase for the utility of these methods, (+)-antofine and (+)-ipalbidine were synthesized in only 8 steps and 24-26% overall yields.