124276-51-3

Basic information

• Product Name: 1-(2-methylphenyl)cyclopropanecarbonitrile
• Synonyms: 1-(2-methylphenyl)cyclopropanecarbonitrile
• CAS NO: 124276-51-3
• Molecular Formula: C11H11N
• Molecular Weight: 157.21174
• Mol File: 124276-51-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-methylphenyl)cyclopropanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methylphenyl)cyclopropanecarbonitrile(124276-51-3)
• EPA Substance Registry System: 1-(2-methylphenyl)cyclopropanecarbonitrile(124276-51-3)

Safety Data

• Hazardous Substances Data: 124276-51-3(Hazardous Substances Data)

Usage

General Description

The chemical 1-(2-methylphenyl)cyclopropanecarbonitrile is a compound with the molecular formula C11H11N. It is classified as a nitrile, containing a carbon-nitrogen triple bond. 1-(2-methylphenyl)cyclopropanecarbonitrile is a derivative of cyclopropane and contains a methylphenyl group attached to the cyclopropane ring. It has potential applications in organic synthesis and pharmaceutical research due to its unique chemical structure. Additionally, it may be used as a building block for the development of new compounds with specific properties or functions. However, it is important to handle this chemical with caution, as nitriles can be toxic and should be used in a controlled environment by trained professionals.

Upstream product

• 95-46-5 2-methylphenyl bromide 
• 5500-21-0 cyclopropropanecarbonitrile 
• 107-04-0 1-Bromo-2-chloroethane 
• 22364-68-7 2-tolylmethylnitrile 

Downstream Products

• 886366-30-9 (1-(o-tolyl)cyclopropyl)methanol 

Relevant articles and documents

Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

We herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the first time. A variety of substrates with α-quaternary carbon centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. We have also demonstrated that the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.

Development of a palladium-catalyzed α-arylation of cyclopropyl nitriles

1,1-Disubstituted aryl cyclopropyl nitriles are useful moieties in biologically active compounds and provide access to a range of cyclopropyl derivatives. Herein, we describe the development of a palladium-catalyzed α-arylation of cyclopropyl, cyclobutyl, and cyclopentyl nitriles that affords these functional groups in one step from a variety of aryl bromides in good to excellent yields. Furthermore, we demonstrate the transformation of aryl cyclopropyl nitriles into aryl trifluoromethyl cyclopropanes.