124288-08-0

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 124288-21-7 7-[5-(4-Fluoro-phenyl)-3-isopropyl-1-phenyl-1H-pyrazol-4-yl]-5-hydroxy-3-oxo-heptanoic acid ethyl ester 
• 116645-15-9 (+/-)-methyl 5-(4-fluorophenyl)-δ-hydroxy-3-(1-methylethyl)-β-oxo-1-phenyl-1H-pyrazole-4-heptanoate 
• 116645-14-8 5-(4-fluorophenyl)-3-(1-methylethyl)-1-phenyl-1H-pyrazole-4-propanal 
• 116645-13-7 2-<2-(1,3-dioxolan-2-yl)ethyl>-1-(4-fluorophenyl)-4-methyl-1,3-pentanedione 
• 116645-17-1 4-bromo-5-(4-fluorophenyl)-3-(1-methylethyl)-1-phenyl-1H-pyrazole 
• 116645-16-0 5-(4-fluorophenyl)-3-(1-methylethyl)-1-phenyl-1H-pyrazole 
• 114433-94-2 1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione 
• 116645-09-1 (+/-)-6-<2-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-phenyl-1H-pyrazol-4-yl>ethyl>tetrahydro-4-hydroxy-2H-pyran-2-one 

Downstream Products

• 124288-09-1 (4S,6S)-4-Benzyloxy-6-{2-[5-(4-fluoro-phenyl)-3-isopropyl-1-phenyl-1H-pyrazol-4-yl]-ethyl}-tetrahydro-pyran-2-one 
• 124288-10-4 3-Benzyloxy-7-[5-(4-fluoro-phenyl)-3-isopropyl-1-phenyl-1H-pyrazol-4-yl]-5-hydroxy-heptanoic acid 
• 124288-12-6 6-{2-[5-(4-fluorophenyl)-3-(1-methylethyl)-1-phenyl-1H-pyrazol-4-yl]ethyl}tetrahydro-4-methoxy-2H-pyran-2-one 

Relevant academic research and scientific papers

Inhibitors of cholesterol biosynthesis. 2. 1,3,5-Trisbustituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles

A series of 1,3,5-trisubstituted pyrazole mevalonolactones were prepared and evaluated for their ability to inhibit the enzyme HMG-CoA reductase in vitro. Since previous studies suggested that the 5-(4-fluorophenyl) and 3-(1-methylethyl) substituents affo