124292-87-1

Upstream product

• 108-20-3 di-isopropyl ether 
• 623-49-4 ethyl cyanoformate 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 898-22-6 triethyl 1,3,5-triazine-2,4,6-tricarboxylate 
• 83566-38-5 diethyl 5-aminoimidazole-2,4-dicarboxylate 
• 26404-26-2 ethyl 2-propyl oxalate 
• 124292-93-9 4-Isopropoxy-2-phenyl-2-trifluoromethyl-2H-oxazol-5-one 
• 124292-97-3 4-isopropoxy-2-phenyl-1,3-oxazol-5(2H)-one 
• 124292-86-0 2-isopropoxy-1-aza-4-oxaspiro[4.5]dec-1-en-3-one 

Relevant academic research and scientific papers

Preparative route to 2-ethoxycarbonylimidazole-4-phosphonate and diethyl imidazole-2,4-dicarboxylate

Practical synthesis of 2-ethoxycarbonylimidazole-4-phosphonate (1a) and diethyl imidazole-2,4-dicarboxylate (1b) are described.

Synthetic method of thiazolecarboxylic chemical intermediate end intermediate

The invention relates to a synthetic method of a thiazolecarboxylic chemical intermediate end intermediate, comprising: (a) mixing ethyl cyanoformate, isopropyl ether and isopropyl alcohol, and cooling under the protection of an inert gas to -20 DEG C to -5 DEG C; (b) mixing water, sodium bicarbonate, ice and methyl tertiary butyl ether, adding the intermediate, and keeping the temperature less than 0 DEG C and pH of weak basicity so as to free the intermediate; (c) adding compound 2 into ethyl alcohol, cooling by means of ice bath under the protection of an inert gas, and adding ammonium chloride to carry out reacting; (d) dissolving compound 3 in dichloromethane, and adding perchloromethylmercaptan under -10 DEG C to -5 DEG C; (e) dissolving compound 4 in ethyl alcohol, and dropwise adding sodium ethoxide-ethanol solution under ice-water bath and inert gas protection to carry out reacting. Therefore, chemical synthesis according to a new route can be provided for 5-ethoxy-1,2,4-thiadiazole-3-carboxylic acid end intermediate.

Method for synthesizing intermediate product thiazolecarboxylic acid chemical intermediate

The invention relates to a method for synthesizing an intermediate product thiazolecarboxylic acid chemical intermediate, comprising the following steps: (a) mixing ethyl cyanoformate, isopropyl etherand isopropanol, and cooling to minus 20- minus 5 DEG C under the inert gas protection; (b) stirring and mixing water, sodium bicarbonate, ice and methyl tert-butyl ether, adding the intermediate, keeping the water temperature below 0 DEG C and keeping the pH to be weakly alkaline so as to free the intermediate; (c) adding the compound 2 into ethanol, cooling under the inert gas protection with an ice bath, and adding ammonium chloride for a reaction; (d) dissolving the compound 3 in dichloromethane and adding perchloromethyl mercaptan at minus 10- minus 5 DEG C. The method of the invention is conducive to industrial batch production of 5-ethoxy-1,2,4-thiadiazole-3-carboxylic acid.

Synthetic method of thiazolecarboxylic acid chemical intermediate

The invention relates to a synthetic method of a thiazolecarboxylic acid chemical intermediate, comprising: (a) mixing ethyl cyanoformate, isopropyl ether and isopropyl alcohol, and cooling to -20 DEGC to -5 DEG C under the protection of an inert gas; (b) mixing water, sodium bicarbonate, ice and methyl tertiary butyl ether, adding an intermediate, keeping water temperature at less than 0 DEG C and pH to weak basicity, so that the intermediate is freed ; (c) adding compound 2 into ethyl alcohol, cooling by ice bath under the protection of an inert gas, adding ammonium chloride, and allowing reacting; (d) dissolving compound 3 into dichloromethane, and adding perchloromethylmercaptan at -10 DEG C to -5 DEG C; (e) dissolving compound 4 into ethyl alcohol, dropwise adding sodium ethoxide-ethanol solution under ice water bath and inert gas protection, and allowing reacting; (f) dissolving compound 5 into tetrahydrofuran, dropwise adding an aqueous solution of lithium hydroxide under ice water bath, and allowing reacting. Therefore, chemical synthesis with a novel route is provided for 5-ethoxy-1,2,4-thiadiazole-3-carboxylic acid.

Synthesis of 4-Alkoxy-1,3-oxazol-5(2H)-ones, Precursors of 1-Alkoxy-Substituted Nitrile Ylides

4-Alkoxy-1,3-oxazol-5(2H)-ones of type 4 and 7 were synthesized by two different methods: oxidation of the 4-(phenylthio)-1,3-oxazol-5(2H)-one 2a with m-chloroperbenzoic acid in the presence of an alcohol gave the corresponding 4-alkoxy derivatives 4, presumably via nucleophilic substitution of an intermediate sulfoxide (Scheme 2).The second approach is the BF3-catalyzed condensation of imino-acetates of type 6 and ketones (Scheme 3).The yields of this more straightforward method were modest due to the competitive formation of 1,3,5-triazine tricarboxylate 8.At 155 deg C, 1,3-oxazol-5(2H)-one 7b underwent decarboxylation leading to an alkoxy-substituted nitrile ylide which was trapped in a 1,3-dipolar cycloaddition by trifluoro-acetophenone to give the dihydro-oxazoles cis- and trans-9 (Scheme 4).In the absence of a dipolarophile, 1,5-dipolar cyclization of the intermediate nitrile ylide yielded isoindole derivatives 10 (Schemes 4 and 5).