1243-66-9Relevant academic research and scientific papers
Method of synthesis of N-alkyl p-toluene sulfonamide
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Paragraph 0016; 0017; 0018, (2017/08/28)
The invention relates to a method of synthesis of N-alkyl p-toluene sulfonamide. In the presence of a PIMs supported solid super acid catalyst, a reaction between anhydrous p-toluene sulfonamide and a primary amine is carried out in the presence of a water absorber 5A-type molecular sieve to obtain a target product. The conversion rate of the anhydrous p-toluene sulfonamide reaches 81.90%, and the yield of the N-alkyl p-toluene sulfonamide can reach 70.53%. The method has high catalyst yield and mild reaction conditions. The catalyst is easy to recycle. The method is low in environment pollution.
Preparation N - alkyl toluene sulfonamide method
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Paragraph 0032; 0033, (2017/08/25)
The invention discloses a method for preparing N-alkyl-p-toluenesulfonamide. The method comprises the following steps: (1) dissolving anhydrous p-toluenesulfonic acid in a dichloromethane solvent, adding a catalyst and a molecular sieve 5A, and controlling the temperature to be 0-40 DEG C; (2) adding primary amine for a reaction, wherein the reaction temperature is 0-40 DEG C; (3) after the reaction is finished, carrying out suction filtration to remove the molecular sieve 5A; (4) washing a filtrate with an acid solution, then carrying out washing with an alkali solution and a salt solution in sequence, carrying out separation to obtain an organic phase, removing a drying agent after drying the organic phase with anhydrous sodium sulfate, and carrying out distillation to recover dichloromethane and obtain a crude product of N-alkyl-p-toluenesulfonamide; (5) carrying out washing with a 50% ethanol water solution, and carrying out weighing after drying. The method has the advantages that the catalyst is used, so that anhydrous p-toluenesulfonic acid can be directly reacted with primary amine in the dichloromethane organic solvent at low temperature; the molecular sieve 5A is added in the reaction between anhydrous p-toluenesulfonic acid and primary amine as a water absorbent, so that water generated in the reaction can be absorbed to ensure a smooth reaction process. According to liquid chromatography analysis, the purity and the yield of N-alkyl-p-toluenesulfonamide exceeds 98% and reaches about 40% respectively.
