124300-25-0

Basic information

• Product Name: 3,4-diethoxymethoxy-2-hydroxy-α-hydroxymethylpropiophenone
• CAS NO: 124300-25-0
• Molecular Weight: 328.362
• Mol File: 124300-25-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,4-diethoxymethoxy-2-hydroxy-α-hydroxymethylpropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-diethoxymethoxy-2-hydroxy-α-hydroxymethylpropiophenone(124300-25-0)
• EPA Substance Registry System: 3,4-diethoxymethoxy-2-hydroxy-α-hydroxymethylpropiophenone(124300-25-0)

Safety Data

• Hazardous Substances Data: 124300-25-0(Hazardous Substances Data)

Upstream product

• 22760-98-1 2,3,4-trihydroxypropiophenone 
• 3188-13-4 ethyl chloromethyl ether 

Downstream Products

• 124300-26-1 3,4-diethoxymethoxy-2-hydroxy-propiophenone 
• 124300-27-2 7,8-diethoxymethoxy-3-methylchromanone 

Relevant articles and documents

A New Synthesis of 3-Methylchromanones from 2-Hydroxypropiophenones

The reaction of 2-hydroxy-3,4-dimethoxypropiophenone (1b) with ethoxymethyl chloride in the presence of K2CO3 and acetone yields only α-hydroxymethyl derivative (3b), whereas 2-hydroxy-4-methoxypropiophenone (1a) gives 3a and the coupled product 2.Similarly 2,4-dihydroxypropiophenone (5) and 2,3,4-trihydroxypropiophenone (1a) yield the α-hydroxymethyl derivatives (7 and 14) and the coupled products (8 and 13).However, 2-hydroxy-4,6-dimethoxypropiophenone (18) affords only the coupled product (19).Compounds 3a, b on reaction with 2percent aq. ethanolic sodium carbonate give the corresponding 3-methylchromanones (4a and 4b).A similar reaction of 7 and 14 eventually affords the corresponding chromanone (10 and 17) in overall 10percent yields.