22760-98-1 Usage
Preparation
Preparation by acylation of pyrogallol with propionic acidin the presence of boron trifluoride in ethyl ether for 1 h at 0° (80%) in the presence of Amberlite IR-120 (cation exchange resin sulfonic acid ? type) at 160° for 2–3 h (78%) Zeokarb 225 was found to be as effectivein the presence of zinc chloride, at 130–140° for 90 min (Nencki ? reaction) (35%) in the presence of 70% perchloric acid at reflux for 1 h (33%) Preparation by reaction of propionyl chloride with pyrogallol and heating 4 h on a water bath (75%) Preparation by acylation of pyrogallol with propionic anhydridein the presence of Amberlite IR-120 (cation exchange resin sulfonic acid type) ? at 160° for 2–3 h (79%) Zeokarb 225 was found to be as effectivein the presence of concentrated sulfuric acid (small drops) at 130° for some ? min (65%) in the presence of zinc chloride, but using a mixture of propionic acid/propionic ? anhydride (85/100) at 135–140° for 40 min, then at r.t. overnight (59%).
Check Digit Verification of cas no
The CAS Registry Mumber 22760-98-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,7,6 and 0 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 22760-98:
(7*2)+(6*2)+(5*7)+(4*6)+(3*0)+(2*9)+(1*8)=111
111 % 10 = 1
So 22760-98-1 is a valid CAS Registry Number.
22760-98-1Relevant articles and documents
Synthesis, antiproliferative, and c-Src kinase inhibitory activities of 4-oxo-4H-1-benzopyran derivatives
Chand, Karam,Tiwari, Rakesh K.,Kumar, Sumit,Shirazi, Amir Nasrolahi,Sharma, Sweta,Van Der Eycken, Erik V.,Parmar, Virinder S.,Parang, Keykavous,Sharma, Sunil K.
, p. 562 - 572 (2015/03/30)
A new class of 4-oxo-4H-1-benzopyran derivatives were synthesized and their antiproliferative activity examined against a panel of three human cancer cell lines, that is, breast carcinoma (MDA-MB-468), ovarian adenocarcinoma (SK-OV-3), and colorectal adenocarcinoma (HT-29). Two compounds, that is, 3-hexyl-7,8-dihydroxy-4-oxo-4H-1-benzopyran and (E)-ethyl 3-(7-methoxy-4-oxo-4H-1-benzopyran-3-yl)acrylate were found to be potent against all three cancer cell lines studied at 50 μM concentration. Also, the inhibitory potency of the compounds was evaluated against active Src kinase. A few of these compounds exhibited modest Src kinase inhibitory activity (IC50 = 52-57 μM). Structure-activity relationship studies with respect to the nature and position of substituents on the lead compounds could be further exploited for the design and development of more potent antiproliferative agents and/or Src kinase inhibitors.
Synthetic studies of the antitumor antibiotic streptonigrin. II. Synthesis of the C D ring portion of streptonigrin
Liao,Wittek,Cheng
, p. 1283 - 1288 (2007/10/06)
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