1243036-01-2Relevant academic research and scientific papers
Solventless DBU-promoted mannich-type reactions of α-amido β-tolylsulfones with diethyl fluoromalonates and diethyl malonates
Kadam, Santosh T.,Kim, Sung Soo
, p. 5647 - 5652 (2010)
Mannich-type reactions of α-amido p-tolylsulfones with diethyl fluoromalonates and diethyl malonates, respectively in presence of catalytic amount of DBU have been developed. A variety of α-amido p-tolylsulfones prepared from aromatic and aliphatic aldehydes reacts with diethyl fluoromalonates and diethyl malonates, respectively under mild reaction conditions to afford α-fluoro β-amino esters and β-amino esters in moderate to good yield.
