124312-54-5

Basic information

• Product Name: 2-(N,4-dimethylphenylsulfonamido)-3-phenylpropanoic acid
• Synonyms: 2-(N,4-dimethylphenylsulfonamido)-3-phenylpropanoic acid
• CAS NO: 124312-54-5
• Molecular Weight: 333.408
• Mol File: 124312-54-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(N,4-dimethylphenylsulfonamido)-3-phenylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N,4-dimethylphenylsulfonamido)-3-phenylpropanoic acid(124312-54-5)
• EPA Substance Registry System: 2-(N,4-dimethylphenylsulfonamido)-3-phenylpropanoic acid(124312-54-5)

Safety Data

• Hazardous Substances Data: 124312-54-5(Hazardous Substances Data)

Upstream product

• 124312-50-1 tert-butyl tosyl-L-phenylalaninate 
• 13505-32-3 N-tosyl-(S)-phenylalanine 
• 124312-51-2 (S)-2-[Methyl-(toluene-4-sulfonyl)-amino]-3-phenyl-propionic acid tert-butyl ester 
• 2566-30-5 N-Methyl-L-phenylalanine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1416475-17-6 N-Methyl-N-tosyl-(S)-phenylalanyl chloride 
• 56564-52-4 N-methyl-D-phenylalanine 

Relevant articles and documents

Iridium-Catalyzed Asymmetric Hydrogenation of N-Alkyl α-Aryl Furan-Containing Imines: an Efficient Route to Unnatural N-Alkyl Arylalanines and Related Derivatives

High throughput experimentation (HTE) has enabled the rapid identification of ligand/precatalyst combinations that facilitate highly enantioselective hydrogenations of prochiral N-alkyl α-aryl ketimines containing a furyl moiety. The chiral amines obtained have proven to be modular precursors in the synthesis of unnatural mono N-alkylated arylalanines and related derivatives. (Figure presented.).

A simple and rapid protocol for N-methyl-α-amino acids

A two step strategy for optically pure N-Protected-N-methyl-α-amino acids starting from N-protected-α-amino acids via reductive cleavage of oxazolidinones using NaCNBH3/TMSCl is described.