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56564-52-4 Usage


H-D-MEPHE-OH HCL, also known as N-alpha-Methyl-D-phenylalanine, is a synthetic amino acid derivative with unique properties. It is characterized by the presence of a methyl group on the alpha nitrogen and a hydrochloride salt form, which contributes to its stability and solubility. H-D-MEPHE-OH HCL has gained attention for its potential applications in various fields, particularly in pharmaceutical research and development.


Used in Pharmaceutical Industry:
H-D-MEPHE-OH HCL is used as a key component in the preparation of phosphate/sulfate ester compounds and their pharmaceutical compositions. These compounds are specifically designed for the inhibition of protein interacting NIMA (PIN 1), a peptidyl-prolyl isomerase enzyme that plays a crucial role in various cellular processes, including cell cycle regulation, signal transduction, and protein folding.
The inhibition of PIN 1 has been implicated in the regulation of various diseases, such as cancer, neurodegenerative disorders, and viral infections. By targeting PIN 1, H-D-MEPHE-OH HCL-based pharmaceutical compositions can potentially offer novel therapeutic strategies for the treatment of these conditions.
Furthermore, the use of H-D-MEPHE-OH HCL in the development of pharmaceutical compositions allows for the exploration of its potential synergistic effects with other drugs or compounds, enhancing the overall efficacy of treatment regimens. This opens up new avenues for research and development in the pharmaceutical industry, paving the way for innovative and effective therapeutic solutions.

Check Digit Verification of cas no

The CAS Registry Mumber 56564-52-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,5,6 and 4 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 56564-52:
144 % 10 = 4
So 56564-52-4 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name (2R)-2-(methylamino)-3-phenylpropanoic acid

1.2 Other means of identification

Product number -
Other names N-methyl-d-phenylalanine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:56564-52-4 SDS

56564-52-4Relevant articles and documents

Isolation, Structure Determination, and Total Synthesis of Hoshinoamide C, an Antiparasitic Lipopeptide from the Marine Cyanobacterium Caldora penicillata

Iwasaki, Arihiro,Ohtomo, Keisuke,Kurisawa, Naoaki,Shiota, Ikuma,Rahmawati, Yulia,Jeelani, Ghulam,Nozaki, Tomoyoshi,Suenaga, Kiyotake

, p. 126 - 135 (2021/01/13)

Hoshinoamide C (1), an antiparasitic lipopeptide, was isolated from the marine cyanobacterium Caldora penicillata. Its planar structure was elucidated by spectral analyses, mainly 2D NMR, and the absolute configurations of the α-amino acid moieties were determined by degradation reactions followed by chiral-phase HPLC analyses. To clarify the absolute configuration of an unusual amino acid moiety, we synthesized two possible diastereomers of hoshinoamide C and determined its absolute configuration based on a comparison of their spectroscopic data with those of the natural compound. Hoshinoamide C (1) did not exhibit any cytotoxicity against HeLa or HL60 cells at 10 μM, but inhibited the growth of the parasites responsible for malaria (IC50 0.96 μM) and African sleeping sickness (IC50 2.9 μM).

Isolation, structure elucidation and biological evaluation of lagunamide D: A new cytotoxic macrocyclic depsipeptide from marine cyanobacteria

Luo, Danmeng,Putra, Masteria Y.,Ye, Tao,Paul, Valerie J.,Luesch, Hendrik

, (2019/02/19)

Lagunamide D, a new cytotoxic macrocyclic depsipeptide, was discovered from a collection of marine cyanobacteria from Loggerhead Key in the Dry Tortugas, Florida. An intramolecular ester exchange was observed, where the 26-membered macrocycle could contract to a 24-membered compound via acyl migration at the 1,3-diol unit, and the transformation product was named lagunamide D'. The planar structures of both compounds were elucidated using a combination of nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectroscopy (HRMS). The absolute configurations were determined on the basis of enantioselective analysis, modified Mosher's analysis, Kishi NMR database, and direct comparison with lagunamide A, a structure closely resembling lagunamide D. Lagunamides A and D displayed low-nanomolar antiproliferative activity against A549 human lung adenocarcinoma cells, while the structural transformation from the 26-membered lagunamide D macrocycle to the 24-membered ring structure for lagunamide D' led to a 9.6-fold decrease in activity. Lagunamide D also displayed potent activity in triggering apoptosis in a dose- and time-dependent manner. Further investigation on the mechanism of action of the lagunamide scaffold is needed to fully explore its therapeutic potential as an anticancer agent.

Odoamide, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Okeania sp.

Sueyoshi, Kosuke,Kaneda, Masato,Sumimoto, Shinpei,Oishi, Shinya,Fujii, Nobutaka,Suenaga, Kiyotake,Teruya, Toshiaki

, p. 5472 - 5478 (2016/08/05)

The bioassay-guided fractionation of the Okinawan marine cyanobacterium Okeania sp. led to the isolation of the 26-membered cyclodepsipeptide odoamide (1). The gross structure of 1 was determined by 1D and 2D NMR analyses, whereas its absolute stereochemistry was determined using a variety of different methods, including synthesis and chemical degradation followed by chiral HPLC analysis. Notably, odoamide (1) showed potent cytotoxicity against HeLa S3 human cervical cancer cells with an IC50value of 26.3?nM.

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