124318-84-9

Upstream product

• 65-71-4 thymin 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 201732-41-4 (R)-1-{[2-O-t-butyldiphenylsilyl-1-O-(4,4'-dimethoxytritylmethyl)ethoxy]methyl}thymine 
• 201732-39-0 (R)-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}thymine 
• 201732-40-3 (R)-1-{[2-O-t-butyldiphenylsilyl-1-(hydroxymethyl)ethoxy]methyl}thymine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 124318-82-7 (S)-1-{[2-O-4,4'-dimethoxytrityl-1-(hydroxymethyl)ethoxy]methyl}thymine 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 

Relevant academic research and scientific papers

A cytosine analogue containing a conformationally flexible acyclic linker for triplex formation at sites with contiguous G-C base pairs

Two nucleoside derivatives of the pyrimidine bases T and m(5ox)C have been prepared with flexible acyclic carbohydrate linkers. A new procedure, beginning with (R)-(-)-2,2-dimethyl-1,3-dioxolane-4-methanol permits the preparation of the stereochemically pure acyclic derivatives of both protected nucleoside analogues without contamination by a problematic rearrangement product. By simply increasing the flexibility of the carbohydrate portion of the am(5ox)C nucleoside derivative. 15-mer triplexes containing five contiguous G-C base pairs exhibit a 7-8 °C increase in T(m) value.