1243250-51-2

Basic information

• Product Name: 1-acetamido-4-phenylbutan-2-yl acetate
• Synonyms: 1-acetamido-4-phenylbutan-2-yl acetate
• CAS NO: 1243250-51-2
• Molecular Weight: 249.31
• Mol File: 1243250-51-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-acetamido-4-phenylbutan-2-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-acetamido-4-phenylbutan-2-yl acetate(1243250-51-2)
• EPA Substance Registry System: 1-acetamido-4-phenylbutan-2-yl acetate(1243250-51-2)

Safety Data

• Hazardous Substances Data: 1243250-51-2(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 117974-11-5 (D,L)-4-phenyl-2-hydroxy-1-butylamine 
• 108-24-7 acetic anhydride 
• 141377-53-9 1-nitro-4-phenylbutan-2-ol 

Relevant articles and documents

Easy kinetic resolution of some β-amino alcohols by Candida antarctica lipase B catalyzed hydrolysis in organic media

Herein, we present an easy and eco-friendly pathway to obtain some enantiomerically enriched β-amino alcohols using essentially as β-blockers. The enzymatic hydrolysis is conducted in hydrophobic organic media, assisted by sodium carbonate and CAL-B. We describe a new and effective procedure in terms of the chemo- and enantioselectivity, which allows for the formation of both enantiomers: the 2-acetamido-1-arylacetates and 2-acetamido-1-arylethanols were obtained with high ee values (up to >99%), while the selectivities reached E >200. The obtained results show a high CAL-B affinity toward the deacylation of the 2-acetamido-1-arylacetates compared to the acylation one. The structure of the 2-acetamido-1-arylacetates had a significant influence on both reactivity and selectivity of the CAL-B catalyzed deacylation. A multigram scale O-deacylation of racemic 2-acetamido-1-phenylacetate has been carried out, giving access both enantiomers with high enantiomeric purity and good isolated chemical yields.