1243257-37-5

Basic information

• Product Name: 2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride
• Synonyms: 2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride
• CAS NO: 1243257-37-5
• Molecular Weight: 744.499
• Mol File: 1243257-37-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride(1243257-37-5)
• EPA Substance Registry System: 2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride(1243257-37-5)

Safety Data

• Hazardous Substances Data: 1243257-37-5(Hazardous Substances Data)

Upstream product

• 119851-28-4 1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one 
• 906005-51-4 2-bromo-1-(2-chloro-4-(4-chlorophenoxy)phenyl)ethanone 
• 1160554-11-9 C₁₈H₁₉Cl₂NO₃ 
• 20357-37-3 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl chloride 
• 53-86-1 [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid 

Relevant articles and documents

Design, synthesis and biological evaluation of 2-(2-aryl-morpholino-4-yl) ethyl esters of indomethacin as potential cyclooxygenase-2 (COX-2) inhibitors

A number of novel 2-(2-arylmorpholino-4-yl)ethyl 1-(4-chlorobenzoyl)-5- methoxy-2-methyl-1H-indol-3-acetate hydrochlorides were synthesized and tested for their cyclooxygenase (COX-1 and COX-2) inhibition properties in vitro. Many of these compounds exhibited moderate to good selective COX-2 inhibition, and subtle structural changes in the substituents on the side chain of the ester moiety altered the inhibitory properties significantly. 2-[2-(4-Butoxyphenyl) morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride (1f), showed good selective COX-2 inhibitory activity (Selective index (SI) 182), which is comparative with celecoxib (SI 214), a COX-2 inhibitor of diarylpyrazoles. While 2-[2-(2,4-dichloro-5-fluorophenyl)morpholino-4-yl] ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride (1g), showed greater selective COX-2 inhibitory activity (SI 358) than celecoxib. Both compounds were identified as compromising derivatives in this class to reduce the side effects generated by nonsteroidal anti-inflammatory drugs (NSAIDs) indomethacin.