1243260-44-7Relevant academic research and scientific papers
Catalytic Synthesis of Saturated Oxygen Heterocycles by Hydrofunctionalization of Unactivated Olefins: Unprotected and Protected Strategies
Shigehisa, Hiroki,Hayashi, Miki,Ohkawa, Haruna,Suzuki, Tsuyoshi,Okayasu, Hiroki,Mukai, Mayumi,Yamazaki, Ayaka,Kawai, Ryohei,Kikuchi, Harue,Satoh, Yui,Fukuyama, Akane,Hiroya, Kou
supporting information, p. 10597 - 10604 (2016/09/04)
A mild, general, and functional group tolerant intramolecular hydroalkoxylation and hydroacyloxylation of unactivated olefins using a Co(salen) complex, an N-fluoropyridinium salt, and a disiloxane reagent is described. This reaction was carried out at ro
Total synthesis and biological evaluation of (-)-apicularen A and its analogues
Palimkar, Sanjay S.,Uenishi, Jun'Ichi,Ii, Hiromi
scheme or table, p. 388 - 399 (2012/02/15)
The total synthesis of (-)-apicularen A (1), a highly cytostatic 12-membered macrolide, and its analogues is described. The convergent and distinct approach not only provides 1, but also opens the opportunity to synthesizeC10-C11 functional analogues of 1
Total synthesis of (-)-Apicularen A
Palimkar, Sanjay S.,Uenishi, Junichi
supporting information; experimental part, p. 4160 - 4163 (2010/11/17)
A convergent total synthesis of (-)-apicularen A, a highly cytostatic 12-membered macrolide, has been accomplished. The key steps include assembling of iodoalkene 8 and aldehyde 9 by Nozaki-Hiyama-Kishi (NHK) coupling, stereospecific construction of 2,6-trans-disubstituted dihydropyran by Pd(II)-catalyzed 1,3-chirality transfer reaction, and Yamaguchi macrolactonization. Introduction of the (2Z,4Z)-heptadienamide moiety in the side chain by an efficient Cu(I)-mediated coupling completed the total synthesis.
