124330-57-0Relevant articles and documents
C-Aryl 5a-carba-β-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes
Ohtake, Yoshihito,Sato, Tsutomu,Matsuoka, Hiroharu,Kobayashi, Takamitsu,Nishimoto, Masahiro,Taka, Naoki,Takano, Koji,Yamamoto, Keisuke,Ohmori, Masayuki,Higuchi, Takashi,Murakata, Masatoshi,Morikawa, Kazumi,Shimma, Nobuo,Suzuki, Masayuki,Hagita, Hitoshi,Ozawa, Kazuharu,Yamaguchi, Koji,Kato, Motohiro,Ikeda, Sachiya
experimental part, p. 4117 - 4127 (2012/09/22)
C-Aryl 5a-carba-β-d-glucopyranose derivatives were synthesized and evaluated for inhibition activity against hSGLT1 and hSGLT2. Modifications to the substituents on the two benzene rings resulted in enhanced hSGLT2 inhibition activity and extremely high h
Synthesis of 5a-Carba-&β-D-glycosylceramide Analogs Linked by Imino, Ether and Sulfide Bridges
Tsunoda, Hidetoshi,Ogawa, Seiichiro
, p. 267 - 278 (2007/10/02)
Carbocyclic analogs of glycoceramides, (2S,3R,4E)-1-(5a-carba-β-D-glycopyranosyl)-2-(hexadecanoylamino)-4-octadecen-3-ols E-3 - E-6, linked by imino, ether and sulfide bridges, were synthesized by coupling of aziridines, as the sphingosine precursors, wit
Cleavage of the Imino Bonds of Validoxylamine A Derivatives with N-Bromosuccinimide
Ogawa, Seiichiro,Miyamoto, Yasunobu,Nakajima, Akihiro
, p. 725 - 728 (2007/10/02)
Reaction of validoxylamine A derivatives with N-bromosuccinimide in aqueous N,N-dimethylformamide resulted in a cleavage of the imino bonds to give rise to synthetically useful protected derivatives of (+)-validamine and valienamine, and the cyclohexanone