1243356-77-5Relevant academic research and scientific papers
Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors
Yang, Hanbiao,Hendricks, Robert T.,Arora, Nidhi,Nitzan, Dov,Yee, Calvin,Lucas, Matthew C.,Yang, Yanli,Fung, Amy,Rajyaguru, Sonal,Harris, Seth F.,Leveque, Vincent J.P.,Hang, Julie Q.,Pogam, Sophie Le,Reuter, Deborah,Tavares, Gisele A.
, p. 4614 - 4619 (2010)
Conformational modeling has been successfully applied to the design of cyclic bioisosteres used to replace a conformationally rigid amide bond in a series of thiophene carboxylate inhibitors of HCV NS5B polymerase. Select compounds were equipotent with th
