Bioorganic and Medicinal Chemistry Letters p. 4614 - 4619 (2010)
Update date:2022-09-26
Topics:
Yang, Hanbiao
Hendricks, Robert T.
Arora, Nidhi
Nitzan, Dov
Yee, Calvin
Lucas, Matthew C.
Yang, Yanli
Fung, Amy
Rajyaguru, Sonal
Harris, Seth F.
Leveque, Vincent J.P.
Hang, Julie Q.
Pogam, Sophie Le
Reuter, Deborah
Tavares, Gisele A.
Conformational modeling has been successfully applied to the design of cyclic bioisosteres used to replace a conformationally rigid amide bond in a series of thiophene carboxylate inhibitors of HCV NS5B polymerase. Select compounds were equipotent with th
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(2010)
