1243539-48-1

Basic information

• Product Name: C₁₈H₂₃N₃O₄
• Synonyms: C₁₈H₂₃N₃O₄
• CAS NO: 1243539-48-1
• Molecular Weight: 345.398
• Mol File: 1243539-48-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₃N₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₃N₃O₄(1243539-48-1)
• EPA Substance Registry System: C₁₈H₂₃N₃O₄(1243539-48-1)

Safety Data

• Hazardous Substances Data: 1243539-48-1(Hazardous Substances Data)

Upstream product

• 6972-27-6 1,3-Dimethyl-6-chlorouracil 
• 46460-23-5 ethyl L-2-amino-4-phenylbutyrate 

Downstream Products

• 1243539-57-2 ethyl 2-{[5-(cyanoacetyl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]amino}-4-phenylbutanoate 

Relevant articles and documents

Enantioconservative synthesis of polysubstituted pyrimido[4,5- b ]azepines

A three-step enantioconservative protocol was developed for the synthesis of polysubstituted pyrimido[4,5-b]azepines. First, 1,3-dimethyl-6-[N-(2- alkoxycarbonylalkyl)amino]uracils were synthesized by nucleophilic substitution of 6-chloro-1,3-dimethyluracil with amino acids. Subsequent acylation of the uracils by a mixture of acetic anhydride and cyanoacetic acid gave the corresponding 5-cyanoacetylated pyrimidines. In the final step, the pyrimidines were subjected to Dieckmann cyclization with a sodium alcoholate in the corresponding alcohol to afford the corresponding pyrimido[4,5-b]azepines. By using uracils of N-monosubstituted amino acids, cyclization was combined with ring opening of the pyrimidine ring system to afford polysubstituted azepines. Georg Thieme Verlag Stuttgart.