1243540-13-7 Usage
Uses
Used in Pharmaceutical Synthesis:
2-Benzyl-3-methoxy-3-oxopropylboronic acid Pinacol Ester is used as a reactant in the synthesis of N-terminal peptidic boronic acids. These peptidic boronic acids are known to act as inhibitors of human ATP-dependent proteinase ClpXP, which is an essential enzyme involved in various cellular processes, including protein degradation and stress response. By inhibiting this enzyme, the compound can potentially be used in the development of therapeutics for conditions related to the dysregulation of protein homeostasis.
Check Digit Verification of cas no
The CAS Registry Mumber 1243540-13-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,3,5,4 and 0 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1243540-13:
(9*1)+(8*2)+(7*4)+(6*3)+(5*5)+(4*4)+(3*0)+(2*1)+(1*3)=117
117 % 10 = 7
So 1243540-13-7 is a valid CAS Registry Number.
1243540-13-7Relevant academic research and scientific papers
N-Terminal peptidic boronic acids selectively inhibit human ClpXP
Knott, Kenneth,Fishovitz, Jennifer,Thorpe, Steven B.,Lee, Irene,Santos, Webster L.
, p. 3451 - 3456 (2010/08/21)
The synthesis and development of N-terminal peptidic boronic acids as protease inhibitors is reported. N-Terminal peptidic boronic acids interrogate the S′ sites of the target protein for selectivity and provide a new strategy that complements the currently known peptidic α-amino boronic acids (C-terminal boronic acids). After screening a series of N-terminal peptidic boronic acids, the first selective inhibitor of human ClpXP, an ATP-dependent serine protease present in the mitochondrial matrix, was discovered. This should facilitate the understanding of the physiological function of this protease The Royal Society of Chemistry 2010.
