1243598-59-5Relevant academic research and scientific papers
PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 1,2-DI(FURAN-2-YL)ETHANE-1,2-DIOLS AND DERIVATES THEREOF
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Page/Page column 32, (2013/09/26)
The invention relates to a process for the preparation of optically active 1,2-diol of formula (S,S)-(I), or alternatively of formula (R,R)-(I) by asymmetric transfer hydrogenation of a compound of formula (II), or a compound of formula (IV), or mixture thereof using an optically active metal compound as catalyst and a specific hydrogen source.
Gold catalysis: Desymmetrization in the furan-yne reaction
Hashmi, A. Stephen K.,Woelfle, Michael,Ata, Filiz,Frey, Wolfgang,Rominger, Frank
experimental part, p. 2297 - 2307 (2010/08/21)
A series of seven symmetric difuryl-diynes were synthesized by a route delivering an anti-configurated product as the major product. The gold-catalyzed conversion of the individual anti- and syn-diastereomers was investigated. The anti-diastereomer in a desymmetrization reaction chemoselectively delivered dihydroindenediols with a furyl and a 2-oxopropyl side chain. The syn-diastereomer was completely converted into oligomeric/polymeric material. Thus, it was not necessary to separate the minor amount of the syn-diastereomers from the product mixtures in order to isolate the dihydroindenediols. Georg Thieme Verlag Stuttgart - New York.
