1243604-80-9Relevant academic research and scientific papers
Discovery of orally available spirodiketopiperazine-based CCR5 antagonists
Nishizawa, Rena,Nishiyama, Toshihiko,Hisaichi, Katsuya,Hirai, Keisuke,Habashita, Hiromu,Takaoka, Yoshikazu,Tada, Hideaki,Sagawa, Kenji,Shibayama, Shiro,Maeda, Kenji,Mitsuya, Hiroaki,Nakai, Hisao,Fukushima, Daikichi,Toda, Masaaki
experimental part, p. 5208 - 5223 (2010/09/18)
Using the previously reported novel spirodiketopiperazine scaffold, the design and synthesis of orally available CCR5 antagonists was undertaken. Compounds possessing a carboxylic acid function in the appropriate position showed improved oral exposure (AU
