124401-46-3

Upstream product

• 124401-50-9 ethyl 1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxylate 
• 124401-44-1 1,2-diisopropyl-4-(4-fluorophenyl)-N-methyl-1H-pyrrole-3-carboxanilide 
• 5153-69-5 4-fluoro-β-nitrostyrene 
• 124401-41-8 1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxanilide 
• 124401-39-4 3-(isopropylamino)-4-methylpent-2(E)-enoic acid anilide 
• 124401-38-3 4-methyl-3-oxo-N-phenylpentanamide 
• 134538-46-8 1-(4-fluorophenyl)-2-nitropropene 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 124401-48-5 1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxaldehyde 
• 124401-53-2 3-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-propenal 
• 124401-51-0 β-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-acrylonitrile 
• 124401-62-3 methyl (3S)-hydroxy-5-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>pent-4(E)-enoate 
• 124401-30-5 methyl 3(RS),5(SR)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate 
• 124401-56-5 methyl 5(RS)-hydroxy-3-oxo-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate 
• 124401-64-5 tert-butyl (5S)-hydroxy-3-oxo-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate 
• 124401-68-9 tert-butyl 3(R),5(R)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate 
• 124401-66-7 tert-butyl 3(R),5(S)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate 
• 124401-60-1 (S)-(-)-2-hydroxy-1,2,2-triphenylethyl (3S)-hydroxy-5-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>pent-4(E)-enoate 
• 124508-42-5 sodium 3(R),5(R)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate 
• 124401-35-0 methyl 3(RS),5(RS)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate 
• 124401-35-0 methyl 3(RS),5(SR)-dihydroxy-7-<1,2-diisopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate 

Relevant academic research and scientific papers

7(1H-pyrrol-3-YL)-substituted 3,5-dihydroxyhept-6-enoic acids, 7-(1H-pyrrol-3-YL)-substituted 3,5-dihyroxyhept-anoic acids, their corresponding delta-lactones and salts, their use as medicaments and pharmaceutical products and intermediates

7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxyhept-6-enoic acids, 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxyheptanoic acids of the formula I STR1 in which A, B, R1, R2, R3, R4 and R5 have the indicated meanings, and the corresponding δ-lactones of the formula II STR2 processes for the preparation of these compounds, their use as medicaments and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formulae I and II are described.

Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 2. Derivatives of 7-(1H-Pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) Acids

A series of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoates (-heptanoates) 1 and 2 have been prepared and tested for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.The most potent compounds exceeded mevinolin's activity in vitro and in vivo.