1244024-13-2Relevant academic research and scientific papers
Diastereoselective conjugate addition of organocuprates to chiral N-enoyl oxazolidinethiones
Sabala, Rocio,Hernandez-Garcia, Luis,Ortiz, Aurelio,Romero, Moises,Olivo, Horacio F.
supporting information; experimental part, p. 4268 - 4270 (2010/11/04)
Figure Presented. Addition of organocuprates, generated in situ using an excess of a 1:2 mixture of CuIDMS and Grignard reagent, to N-enoyl oxazolidinethiones in the presence of excess TMSI gave preferentially the anti diastereomer where the addition took place when the conformation of the substrate was syn-s-cis. The reaction was investigated with indene-based and three different phenyl glycine derived oxazolidinethiones.
