1244045-25-7Relevant academic research and scientific papers
Synthesis of p38 MAP kinase inhibitor BIRB 796 and analogs via copper-mediated N-arylation reaction
Tan, Zhulin,Song, Jinhua J.,Reeves, Jonathan T.,Fandrick, Daniel R.,Lee, Heewon,Campbell, Scot,Yee, Nathan K.
supporting information; experimental part, p. 4547 - 4551 (2010/10/02)
Direct N-arylation of urea (5) with various arylboronic acids mediated by cupric acetate furnished BIRB796 and a range of N-substituted BIRB796 analogs in good to moderate yields in one step. Urea (5) was readily synthesized from commercially available compounds.
