285984-08-9Relevant academic research and scientific papers
Synthesis of p38 MAP kinase inhibitor BIRB 796 and analogs via copper-mediated N-arylation reaction
Tan, Zhulin,Song, Jinhua J.,Reeves, Jonathan T.,Fandrick, Daniel R.,Lee, Heewon,Campbell, Scot,Yee, Nathan K.
supporting information; experimental part, p. 4547 - 4551 (2010/10/02)
Direct N-arylation of urea (5) with various arylboronic acids mediated by cupric acetate furnished BIRB796 and a range of N-substituted BIRB796 analogs in good to moderate yields in one step. Urea (5) was readily synthesized from commercially available compounds.
Aromatic heterocyclic compounds as antiinflammatory agents
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, (2008/06/13)
Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.
