1244059-04-8

Basic information

• Product Name: phenyl (6-bromo-1,3-benzothiazol-2-yl)carbamate
• Synonyms: phenyl (6-bromo-1,3-benzothiazol-2-yl)carbamate
• CAS NO: 1244059-04-8
• Molecular Weight: 349.208
• Mol File: 1244059-04-8.mol

Chemical Properties

• CAS DataBase Reference: phenyl (6-bromo-1,3-benzothiazol-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl (6-bromo-1,3-benzothiazol-2-yl)carbamate(1244059-04-8)
• EPA Substance Registry System: phenyl (6-bromo-1,3-benzothiazol-2-yl)carbamate(1244059-04-8)

Safety Data

• Hazardous Substances Data: 1244059-04-8(Hazardous Substances Data)

Upstream product

• 106-40-1 4-bromo-aniline 
• 15864-32-1 2-amino-6-bromobenzothiazole 
• 1885-14-9 phenyl chloroformate 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of 4-Phenoxyquinoline Derivatives Containing Benzo[d]thiazole-2-yl Urea as c-Met Kinase Inhibitors

A series of novel 4-phenoxyquinoline derivatives containing the benzo[d]thiazole-2-yl urea moiety were synthesized and evaluated for their cytotoxicity against the HT-29, MKN-45, and H460 cell lines. The structures of the target compounds were confirmed by 1H NMR and MS spectra. Most of them showed moderate to excellent potency against the three tested cell lines. Especially, compound 23 was identified a promising agent (c-Met IC50 = 17.6 nM), showing the most potent anticancer activities with IC50 values of 0.18, 0.06, and 0.01 μM against the HT-29, MKN-45, and H460 cell lines, respectively. The docking results of 23 with the c-Met kinase model 3LQ8 showed a specific binding mode between the ligand and the target protein.

FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE

The invention relates to compounds of formula (I) for the regulation of phosphoinositides 3-kinases activity and related diseases.