124413-44-1

Basic information

• Product Name: 4-cyano-3-(p-methoxyphenyl)isothiazole
• Synonyms: 4-cyano-3-(p-methoxyphenyl)isothiazole
• CAS NO: 124413-44-1
• Molecular Weight: 216.263
• Mol File: 124413-44-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-cyano-3-(p-methoxyphenyl)isothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-cyano-3-(p-methoxyphenyl)isothiazole(124413-44-1)
• EPA Substance Registry System: 4-cyano-3-(p-methoxyphenyl)isothiazole(124413-44-1)

Safety Data

• Hazardous Substances Data: 124413-44-1(Hazardous Substances Data)

Upstream product

• 17325-02-9 (E)-3-Amino-3-(4-methoxy-phenyl)-acrylonitrile 
• 124413-27-0 3-amino-2-cyano-4'-methoxythiocinnamaldehyde 

Relevant articles and documents

Synthesis of 2-llkoxycarbonyl enamino thioaldehydes and selenaldehydes (as Pentacarbonyltungsten(0) Complexes). Improved synthesis of simple and 2-cyano enamino thioaldehydes and some chemical reactions of these compounds

A series of stable 2-alkoxycarbonyl enamino thioaldehydes (2a-g) were synthesized by solvolysis of the Vilsmeier salts (1) with aqueous or methanolic sodium hydrogen sulphide. Three 2-alkoxycarbonyl enamino selenaldehydes were obtained as the pentacarbonyltungsten(o) complexes (7a-c). The 2-cyano and simple enamino thioaldehydes (3a-m) and (6a-j) (including some new homologues obtained by an improved synthetic method) are described. Some reactions of 2-cyano and 2-alkoxycarbonyl enamino thioaldehydes were examined e.g. oxidation with MCPBA to give the isothiazoles (8). The symmetrically tetrasubstituted pyridines (9) were produced by bimolecular cyclisation under acidic conditions: hydrolysis in acidic 95% aq. EtOH gave the enamino aldehydes (11) and aroylacetonitriles (12) together with (9). The imines (13) were formed in good yield on reaction with primary amines.