17325-02-9

Upstream product

• 874-90-8 4-methoxybenzonitrile 
• 75-05-8 acetonitrile 
• 104-47-2 p-methoxybenzylnitrile 

Downstream Products

• 3672-47-7 3-oxo-3-(4'-methoxyphenyl)propanenitrile 
• 128421-58-9 3-(2,6-Dimethyl-phenyl)-5-(4-methoxy-phenyl)-isoxazole-4-carbonitrile 
• 128421-42-1 (Z)-2-[3-(2,6-Dimethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-1-(4-methoxy-phenyl)-vinylamine 
• 95024-26-3 3-(4-Methoxy-phenyl)-3-oxo-2-[5-phenyl-[1,2]dithiol-(3Z)-ylidene]-propionitrile 
• 1233219-50-5 3-acetylamino-3-(p-methoxyphenyl)acrylonitrile 
• 124413-47-4 3,5-dicyano-2,6-di-p-methoxyphenylpyridine 
• 124413-57-6 3-amino-2-(N-phenylformimidoyl)-4'-methoxyallocinnamonitrile 
• 124413-58-7 3-amino-2-(N-cyclohexylformimidoyl)-4'-methoxyallocinnamonitrile 
• 124413-44-1 4-cyano-3-(p-methoxyphenyl)isothiazole 

Relevant academic research and scientific papers

Acid-promoted rapid solvent-free access to substituted 1,4-dihydropyridines from β-ketothioamides

β-Ketothioamides (KTAs) have been used as building blocks with aldehydes and β-enaminonitriles for synthesis of 1,4-dihydropyridines in the presence of AcOH under solvent-free conditions within 5 min. This new strategy exhibits remarkable features such as high chemoselectivity, mild reaction conditions, easily available substrates, and good yields.

Enantioselective biocatalytic hydrolysis of β-aminonitriles to β-amino-amides using Rhodococcus rhodochrous ATCC BAA-870

A range of β-aminonitriles (3-amino-3-phenylpropanenitrile and derivatives) were synthesised by reaction of various benzonitriles with acetonitrile and subsequent reduction of the resulting acrylonitrile products. These compounds were hydrolysed to the co

Rhodium-catalyzed asymmetric hydrogenation of β-acetylamino acrylonitriles

The rhodium-catalyzed asymmetric hydrogenation of β-acetylamino acrylonitriles was investigated by using monophosphine and bisphosphine ligands. It was found that an Rh-QuinoxP complex exhibited high enantioselectivities for β-aryl substituted β-acetylamino acrylonitriles and the Rh-JosiPhos CyPF-t-Bu complex was proven to be effective for the hydrogenation of tetrasubstituted olefins from cyclic β-acetylamino acrylonitriles.

Highly efficient RhI-catalyzed asymmetric hydrogenation of β-amino acrylonitriles

(Figure Presented) It takes two to TangPhos: β-Amino acrylonitriles can be readily prepared from acetonitriles. Both of the E/Z isomers undergo hydrogenation with excellent enantioselectivity by using the Rh-TangPhos (TangPhos = l, 1'-ditert-butyl-(2, 2')-diphospholane) catalyst system. The products, chiral β-amino nitriles, are valuable chiral building blocks for many drugs.

A new expedient route to 2,6-diaryl-3-cyano-4- (trifluoromethyl)pyridines

1-Aryl-4,4,4-trifluoro-1,3-butanediones 1 react with β-amino-β- arylacrylonitrile 2, readily available from acetonitrile with aryl nitriles in the presence of potassium t-butoxide, to afford the corresponding 2,6- diaryl-3-cyano-4-(trifluoromethyl)pyridin