124424-22-2Relevant articles and documents
Penicillium sclerotiorum catalyzes the conversion of herbertenediol into its dimers: Mastigophorenes A and B
Harinantenaina, Liva,Noma, Yoshiaki,Asakawa, Yoshinori
, p. 256 - 257 (2005)
Herbertenediol was subjected to biotransformation by Penicillium sclerotiorum. Spectral data analysis of the converted metabolites revealed that the neurotrophic active compounds, mastigophorenes A and B, dimeric to the substrate were formed.
Total syntheses of (-)-herbertenediol, (-)-mastigophorene A, and (-)- mastigophorene B. Combined utility of chiral bicyclic lactams and chiral aryl oxazolines
Degnan, Andrew P.,Meyers
, p. 2762 - 2769 (2007/10/03)
A nonracemic bicyclic lactam has been used to construct a chiral cyclopentane containing vicinal quaternary carbon centers in optically pure form, which is common to all of the title compounds. An oxazoline-mediated asymmetric Ullmann coupling was then utilized to establish chirality about the biaryl axis of mastigophorenes A and B. Through the course of this synthesis, it was clearly demonstrated that smaller chiral auxiliaries lead to higher levels of atroposelection, a previously unknown phenomenon of the asymmetric Ullmann coupling.