124437-35-0Relevant academic research and scientific papers
PYRIDAZINE DERIVATIVES AND USE THEREOF AS MEDICAMENTS FOR TREATING MICRORNA VIRAL INFECTION
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Paragraph 0054, (2013/06/27)
Disclosed are pyridazine derivatives represented by formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification.
Pharmacophore-based design, synthesis, and biological evaluation of novel chloro-pyridazine piperazines as human rhinovirus (HRV-3) inhibitors
Wang, Hongliang,Xiao, Junhai,Gao, Dapeng,Zhang, Xian,Yan, Hui,Gong, Zehui,Sun, Tinmin,Li, Song
, p. 1057 - 1059 (2011/03/21)
A series of chloro-pyridazine piperazines were developed based on the structure of human rhinovirus (HRV) capsid-binding inhibitors with proven activity using a pharmacophore model. A preliminary evaluation demonstrated potent activity against HRV-3 with low cytotoxicity. A docking analysis indicated that 8a could fit into, and form tight interactions (e.g., H-bonds, σ-π effect) with the active site in VP1.
