1244547-05-4Relevant academic research and scientific papers
Rapid synthesis of highly functionalised α-amino amides and medium ring lactones using multicomponent reactions of amino alcohols and isocyanides
Bachman, Martin,Mann, Sam E.,Sheppard, Tom D.
experimental part, p. 162 - 170 (2012/01/12)
Four-component reactions between amino alcohols, aldehydes, isocyanides and thiols proceed rapidly under microwave or conventional heating at 60 °C in methanol. The reaction is successful with a wide range of components and gives access to potentially dru
Isocyanide based multicomponent reactions of oxazolidines and related systems
Waller, Robert W.,Diorazio, Louis J.,Taylor, Brian A.,Motherwell, William B.,Sheppard, Tom D.
experimental part, p. 6496 - 6507 (2010/10/03)
N-Alkyloxazolidines react in a multicomponent reaction with carboxylic acids and isocyanides to give N-acyloxyethylamino acid amides. The previously reported reaction conditions were improved using a design of experiments approach (DoE). Under the optimis
