1244564-33-7Relevant academic research and scientific papers
Antimicrobial 1,3,4-trisubstituted-1,2,3-triazolium salts
Fletcher, James T.,Sobczyk, Jill M.,Gwazdacz, Sarah C.,Blanck, Aaron J.
supporting information, p. 3320 - 3323 (2018/09/17)
A series of 1,3,4-trisubstituted-1,2,3-triazolium bromide salts were prepared by efficient two-step sequences of azide-alkyne cycloaddition and benzylic substitution. The antimicrobial activity of each triazolium salt and correlating triazole precursor wa
Chemical synthesis and biological evaluation of triazole derivatives as inhibitors of InhA and antituberculosis agents
Menendez, Christophe,Chollet, Aurélien,Rodriguez, Frédéric,Inard, Cyril,Pasca, Maria Rosalia,Lherbet, Christian,Baltas, Michel
, p. 275 - 283 (2012/07/30)
A series of triazoles have been prepared and evaluated as inhibitors of InhA as well as inhibitors of Mycobacterium tuberculosis H37R v. Several of these new compounds possess a good activity against InhA, particularly compounds 17 and 18 for which molecular docking has been performed. Concerning their activities against M. tuberculosis H 37RV strain, two of them, 3 and 12, were found to be good inhibitors with MIC values of 0.50 and 0.25 μg/mL, respectively. Particularly, compound 12 presenting the best MIC value of all compounds tested (0.6 μM) is totally inactive against InhA.
Copper(I)-catalyzed azide-alkyne cycloadditions in ionic liquids under amine-free conditions
Vecchi, Alessandra,Chambery, Angela,Chiappe, Cinzia,Marra, Alberto,Dondoni, Alessandro
experimental part, p. 2043 - 2048 (2010/08/19)
Copper(I) iodide catalyzed cycloadditions of various combinations of structurally diverse organic azides and terminal alkynes were carried out in a commercially available, polyoxygenated ionic liquid (AMMOENG 100) without addition of free amine. Unlike th
