124458-17-9

Usage

Chemical compound

2-[2-(Phenylamino)thiazol-4-yl]ethanamine

Structure

Contains a phenylamino group

Uses

Organic synthesis, pharmaceutical research, drug development, agrochemicals, materials science

Potential applications

Development of new drugs, pharmaceuticals

Properties

Thiazole derivative, structural properties, biological activities

Potential benefits

Various applications in the chemical industry, further potential uses and benefits with continued study.

Upstream product

• 103-85-5 monophenylthiourea 
• 62-53-3 aniline 
• 4921-82-8 1-benzoyl-3-phenylthiourea 
• 124458-16-8 2-Phenylamino-4-[(2-N-phthalimido)ethyl]thiazole 

Relevant academic research and scientific papers

Histamine H1 receptor ligands - Part II. Synthesis and in vitro pharmacology of 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives

New 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives were prepared and tested in vitro as H1 receptor antagonists. The compounds with 2-phenylamino substitution with meta-halide substituents at the phenyl ring, showed weak H1-antagonistic activity (pA2: 4.62-5.04) and this activity was completely lost in the case of meta-methyl substituent (pA2 : 4). When the phenylamino group was replaced by benzhydryl groups of classic antihistamines, the resulting compounds exhibited slightly improved H1-antagonistic activity (at the meta-position pA2: 6.38-6.15; at the para-position pA2: 6.04-5.87).

Heterocycylic-substituted quinoline-carboxylic acids

1-Substituted-6-fluoro-7-heterocyclic-1,4-dihydroquino-1-(or dihydronaphthyridin)-4-one carboxylic acids have antibacterial properties. The 7-heterocyclic group is a bicyclic group, one of the rings of which is saturated and the other ring of which is unsaturated.