1244652-27-4Relevant academic research and scientific papers
Synthesis of 4-functionalized-1H-indoles from 2,3-dihalophenols
Sanz, Roberto,Guilarte, Veronica,Garcia, Nuria
supporting information; experimental part, p. 3860 - 3864 (2010/09/17)
A new synthesis of 4-halo-1H-indoles has been developed from easily available 2,3-dihalophenol derivatives. The key steps are Smiles rearrangement and a one-pot or stepwise Sonogashira coupling/NaOH-mediated cyclization. Subsequent functionalization allows access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles.
Bronsted acid catalyzed alkylation of indoles with tertiary propargylic alcohols: Scope and limitations
Sanz, Roberto,Miguel, Delia,Martinez, Alberto,Gohain, Mukut,Garcia-Garcia, Patricia,Fernandez-Rodriguez, Manuel A.,Alvarez, Estela,Rodriguez, Felix
supporting information; experimental part, p. 7027 - 7039 (2011/02/28)
Direct alkylation of indoles with a wide variety of tertiary propargylic alcohols under Bronsted acid catalysis conditions has been studied. A general and environmentally friendly method for the synthesis of 3-propargylated indoles with quaternary carbon
