124471-31-4

Upstream product

• 75-52-5 nitromethane 
• 7311-34-4 3,5-dimethoxybenzaldehdye 

Downstream Products

• 91252-41-4 2-hydroxy-2-(3,5-dimethoxyphenyl)ethylamine 

Relevant academic research and scientific papers

Cyclen-catalyzed Henry reaction under neutral conditions

A convenient cyclen-catalyzed Henry reaction of aldehydes with nitroalkanes under mild and neutral conditions is reported. This procedure constitutes the first cyclen-catalyzed synthesis of nitroalcohols and is adapted to the condensation of both aromatic and aliphatic aldehydes with nitromethane in THF at room temperature without addition of stoichiometric amount of the base. A wide range of substrates, β-nitroalcohols, were obtained in moderate to good yields (up to 98%) using this methodology.

Highly efficient nanosized mesoporous CuMgAl ternary oxide catalyst

Highly efficient nanosized mesoporous CuMgAl ternary oxide catalysts are provided.

One-Pot Enzyme Cascade Catalyzed Asymmetrization of Primary Alcohols: Synthesis of Enantiocomplementary Chiral β-Nitroalcohols

Biocatalytic asymmetrization of inexpensive and stable primary alcohols to prepare enantioenriched β-nitroalcohols is an important development in green chemistry for the production of chiral pharmaceutical intermediates. Herein, we report a one-pot, two-step cascade reaction sequence in which first benzylic alcohols were oxidized to produce corresponding benzaldehydes using horse liver alcohol dehydrogenase (HLADH). The in situ generated aldehydes were then reacted in a biphasic medium with nitromethane by Arabidopsis thaliana hydroxynitrile lyase (AtHNL) or Baliospermum montanum HNL (BmHNL) catalyzed Henry reaction to produce stereoselective β-nitroalcohols with (R) or (S) configuration, respectively. Using HLADH-AtHNL, (R)-β-nitroalcohols were obtained in up to 64% conversion, and HLADH-BmHNL, (S)-β-nitroalcohols in up to 70% conversion, while in both cases excellent stereoselectivity (up to >99% ee) was achieved. The concept was proven by functionalization of sp3 C?H bond of ten simple achiral benzylic alcohols to enantiocomplementary chiral β-nitroalcohols. (Figure presented.).

Novel α1- adrenergic receptor agonists

The present invention relates to a novel andalpha;1-adrenergic receptor agonist, and more particularly, to a novel analogue of midodrine which is andalpha;1-adrenergic receptor agonist. The midodrine analogue of the present invention increase an expression of p-AMPK, PPARanddelta;, PGC-1andalpha;, which are essential for maintaining and regulating in vivo energy metabolism activity, thereby being usefully used for preventing or treating diseases (such as metabolic diseases, cardiovascular diseases, inflammatory diseases, etc.) in which activation of AMPK is required.COPYRIGHT KIPO 2018

Copper complex of aminoisoborneol schiff base Cu2(SBAIB-d) 2: An efficient catalyst for direct catalytic asymmetric nitroaldol (henry) reaction

A new bifunctional copper complex of the aminoisoborneol Schiff base - Cu2(SBAIB-d)2 - has been developed for the effective direct catalytic asymmetric Henry reaction. One mol% of this catalyst produces the expected Henry products in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee). The utility of the present catalyst was also extended to the Henry reaction with nitroethane and 1-nitropropane that furnished the corresponding products in moderate to high yields (up to 99%) with moderate to high enantioselectivities of syn (up to 98% ee) and anti (up to 98% ee) diastereomers. The highlights of this catalytic system are easy manipulation, air and moisture tolerance, the need for 1 mol% of an easily synthesizable catalyst and the high enantioselectivities achieved for a wide range of substrates. Copyright