1244763-58-3Relevant academic research and scientific papers
2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors
Cai, Jiaqiang,Bennett, D. Jonathan,Rankovic, Zoran,Dempster, Maureen,Fradera, Xavier,Gillespie, Jonathan,Cumming, Iain,Finlay, William,Baugh, Mark,Boucharens, Sylviane,Bruin, John,Cameron, Kenneth S.,Hamilton, William,Kerr, Jennifer,Kinghorn, Emma,McGarry, George,Robinson, John,Scullion, Paul,Uitdehaag, Joost C.M.,Van Zeeland, Mario,Potin, Dominique,Saniere, Laurent,Fouquet, Andre,Chevallier, Francois,Deronzier, Hortense,Dorleans, Cecile,Nicolai, Eric
, p. 4447 - 4450 (2010)
Starting from previously disclosed equally potent cathepsin K and S inhibitor 4-propyl-6-(3-trifluoromethylphenyl)pyrimidine-2-carbonitrile 1, a novel 2-phenyl-9H-purine-6-carbonitrile scaffold was identified to provide potent and selective cathepsin S inhibitors.
