121058-86-4

Basic information

• Product Name: N-blocked-5'-O-DMT-2'-O-TBDMS CED adenosine phosphoramidit
• Synonyms: N-blocked-5'-O-DMT-2'-O-TBDMS CED adenosine phosphoramidit
• CAS NO: 121058-86-4
• Molecular Formula: C₅₄H₆₈N₇O₉PSi
• Molecular Weight: 1018.24
• Mol File: 121058-86-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-blocked-5'-O-DMT-2'-O-TBDMS CED adenosine phosphoramidit(CAS DataBase Reference)
• NIST Chemistry Reference: N-blocked-5'-O-DMT-2'-O-TBDMS CED adenosine phosphoramidit(121058-86-4)
• EPA Substance Registry System: N-blocked-5'-O-DMT-2'-O-TBDMS CED adenosine phosphoramidit(121058-86-4)

Safety Data

• Hazardous Substances Data: 121058-86-4(Hazardous Substances Data)

Upstream product

• 121058-83-1 5′-O-(dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N⁶-phenoxyacetyladenosine 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 701-99-5 Phenoxyacetyl chloride 
• 58-61-7 adenosine 
• 121076-16-2 5'-O-dimethoxytrityl-N₆-phenoxyacetyladenosine 
• 10457-15-5 O^2'_,O3'_,O5'-tris-trimethylsilanyl-adenosine 
• 119824-65-6 N⁶-phenoxyacetyladenosine 

Downstream Products

• 897626-88-9 C₄₆H₆₂N₇O₇PSi 
• 121058-83-1 5′-O-(dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N⁶-phenoxyacetyladenosine 

Relevant articles and documents

THE USE OF LABILE BASE PROTECTING GROUPS IN OLIGORIBONUCLEOTIDE SYNTHESIS

The use of phenoxyacetyl group for the protection of the exocyclic amino function of purine bases and acetyl group for cytosine in oligonucleotide synthesis by the cyanoethylphosphoramidite approach is described.A side reaction - i.e. partial replacement of phenoxyacetyl group of protected guanines by acetyl group - was observed during the capping step.It can be avoided by the use of phenoxyacetic anhydride in place of acetic anhydride.