124492-04-2 Usage
Uses
Used in Pharmaceutical Research:
(S)-1,4-DITHIA-7-AZASPIRO[4.4]NONANE-8-CARBOXYLIC ACID is utilized as a key intermediate in the synthesis of pharmaceutical compounds due to its distinctive spiro ring structure, which allows for the creation of molecules with specific interactions with biological targets, potentially leading to the development of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, (S)-1,4-DITHIA-7-AZASPIRO[4.4]NONANE-8-CARBOXYLIC ACID serves as a valuable building block for the construction of complex organic molecules. Its unique structural features can be leveraged to form new chemical entities with potential applications across various industries.
Further research and experimentation are necessary to fully explore and understand the compound's properties and to unlock its complete potential in diverse scientific and technological applications.
Check Digit Verification of cas no
The CAS Registry Mumber 124492-04-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,4,9 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 124492-04:
(8*1)+(7*2)+(6*4)+(5*4)+(4*9)+(3*2)+(2*0)+(1*4)=112
112 % 10 = 2
So 124492-04-2 is a valid CAS Registry Number.
124492-04-2Relevant academic research and scientific papers
Angiotensin Converting Enzyme Inhibitors: Spirapril and Related Compounds
Smith, Elizabeth M.,Swiss, Gerald F.,Neustadt, Bernard R.,McNamara, Paul,Gold, Elijah H.,et al.
, p. 1600 - 1606 (2007/10/02)
The synthesis of spirapril (5), spiraprilat (25), their RSS stereoisomers, and their glycyl (18b) and lysyl (36, 37) analogues is described.These compounds were evaluated in vivo for inhibition of angiotensin converting enzyme (ACE), and selected compounds were evaluated for in vitro ACE inhibition (spirapril ID50 16 μg/kg; spiraprilat IC50 0.8 nM, ID50 8 μg/kg).In anesthetized rats, iv, esters 5 and 36 are more potent than enalapril, and diacids 25 and 37 are more potent than enalaprilat in vitro.In the conscious rats, orally, 5 and enalapril (2) showed potent and sustained activity at doses of 0.03-1 and 0.1-1 mg/kg, respectively.From this work, spirapril was selected for clinical evaluation as an antihypertensive agent.
