124493-37-4Relevant academic research and scientific papers
Production process of 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol
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Page/Page column 0027-0030, (2020/07/12)
The invention discloses a production process of 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol. The process comprises the following steps: taking p-chloroiodobenzene and diethyl malonate as initialraw materials; firstly, subjecting the p-chloroiodobenzene and diethyl malonate to coupling reaction to prepare a compound 3; carrying out alkylation reaction on the compound 3 and methyl iodide to obtain a compound 4; reacting the compound 4 with lithium aluminum hydride to obtain a 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol crude product; and finally, subjecting the 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol to a recrystallization procedure, thus obtaining the target product 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol.
Arylation of Diethyl Alkylmalonates: Synthetic Route to Diethyl Alkyl(substituted Aryl)malonates with the Aid of Temporary Arene Complexation by the Cyclopentadienyliron Moiety
Piorko, Adam,Abd-El-Aziz, Alaa S.,Lee, Choi Chuck,Sutherland, Ronald G.
, p. 469 - 475 (2007/10/02)
Nucleophilic substitution of chlorine in the ironcyclopentadienyl hexafluorophosphates of chlorobenzene, isomeric chlorotoluenes and dichlorobenzenes (1) with the anions generated from diethyl alkylmalonates (2) and (3) leads to the formation of ironcyclopentadienyl complexes of diethyl alkyl(substituted phenyl)malonates (4) and (5).An excess of the anion employed in reactions with the m- and p-dichlorobenzene complexes leads to substitution of both chlorine atoms and formation of isomeric phenylenedimalonate complexes (8).Malonyl cations (4) and (5) possessing a chloro substituent on the complexed phenyl ring provide the possibility of further modifications of phenyl ring substituents via substitution or addition reactions .The described complexes have been demetallated giving diethyl alkyl(substituted phenyl)malonates in >50percent overall yield from the cations (1).All the complexes and compounds have been fully characterized.This approach to the synthesis of the diethyl alkyl(substituted phenyl)malonates which are intermediates in the synthesis of important biologically active barbiturates is easy, efficient, and currently the most general in the area.
