19677-37-3

Basic information

• Product Name: DIETHYL 4-CHLOROPHENYL MALONATE
• Synonyms: DIETHYL 4-CHLOROPHENYL MALONATE;RARECHEM AL BI 0611;2-(4-Chlorophenyl)-malonic acid diethylester;4-chlorophenyl 1-ethyl 2-ethylpropanedioate;2-(4-chlorophenyl)Malonic acid;Diethyl 2-(4-chlorophenyl)Malonate;PROPANEDIOIC ACID, 2-(4-CHLOROPHENYL)-, 1,3-DIETHYL ESTER;Diethyl (p-chlorophenyl)malonate
• CAS NO: 19677-37-3
• Molecular Formula: C₁₃H₁₅ClO₄
• Molecular Weight: 270.71
• Mol File: 19677-37-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 334.1°Cat760mmHg
• Flash Point: 125.2°C
• Appearance: /
• Density: 1.206g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.06±0.46(Predicted)
• CAS DataBase Reference: DIETHYL 4-CHLOROPHENYL MALONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL 4-CHLOROPHENYL MALONATE(19677-37-3)
• EPA Substance Registry System: DIETHYL 4-CHLOROPHENYL MALONATE(19677-37-3)

Safety Data

• Hazardous Substances Data: 19677-37-3(Hazardous Substances Data)

Usage

Description

DIETHYL 4-CHLOROPHENYL MALONATE, a chemical compound with the chemical formula C13H14ClNO4, is primarily used in the pharmaceutical industry as an intermediate for producing other substances. It is a colorless liquid that is relatively stable under standard conditions but may decompose when exposed to heat. Although it may pose a slight health risk in cases of inhalation or direct contact, it generally has a low level of toxicity. Proper storage is essential to prevent fire or explosion hazards in high heat or reactive agent conditions. It is also utilized in scientific research due to its potentially useful properties.

Uses

Used in Pharmaceutical Industry:
DIETHYL 4-CHLOROPHENYL MALONATE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its role in the production process is crucial for creating a range of medications that can address different health conditions.
Used in Scientific Research:
DIETHYL 4-CHLOROPHENYL MALONATE is employed as a research compound in various scientific studies. Its unique properties make it a valuable tool for understanding chemical reactions and exploring new avenues in drug development and other applications.

Upstream product

• 64-17-5 ethanol 
• 147795-56-0 ethyl 2-(4-chlorophenyl)-2-cyanoacetate 
• 7519-91-7 tris(4-chlorophenyl)boroxine 
• 105-53-3 diethyl malonate 
• 19213-72-0 ethyl 1-imidazolecarboxylate 
• 14062-24-9 4-chloro-benzeneacetic acid, ethyl ester 
• 623-49-4 ethyl cyanoformate 
• 106-39-8 bromochlorobenzene 
• 86409-62-3 tricarbonyl(1,4-dichlorobenzene)chromium⁽⁰⁾ 
• 140-53-4 p-chlorobenzyl cyanide 
• 1878-66-6 4-chlorophenylacetic Acid 
• 637-87-6 1-Chloro-4-iodobenzene 
• 105-58-8 Diethyl carbonate 
• 106-46-7 para-dichlorobenzene 

Downstream Products

• 199436-87-8 2-(4-Chloro-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-malonic acid diethyl ester 
• 62485-32-9 dimethyl 2-[3-(4-chlorophenyl)-cyclobutyl]-2-oxoethylphosphonate 
• 1276630-41-1 2,4-dichloro-3-(4-chlorophenyl)-6-methoxyquinolin 
• 1286957-62-7 4-chloro-3-(4-chlorophenyl)-6-methoxyquinolin-2(1H)-one 
• 1286017-21-7 3-(4-chlorophenyl)-6-methoxy-2-oxo-1,2-dihydroquinoline-4-carbonitrile 
• 1276587-86-0 3-(4-chlorophenyl)-4-hydroxy-6-methoxyquinolin-2(1H)-one 
• 124493-37-4 diethyl p-chlorophenyl(methyl)malonate 
• 872181-15-2 2-[2-(4-chlorophenyl)-3-methoxymethoxypropoxy]-6-fluorobenzonitrile 
• 872181-14-1 2-(4-chlorophenyl)-3-methoxymethoxypropan-1-ol 
• 58007-39-9 4-(4-chloro-phenyl)-2-(4-nitro-benzylidene)-3,5-dioxo-isoxazolidinium betaine 
• 58007-36-6 4-(4-chloro-phenyl)-2-(4-dimethylamino-benzylidene)-3,5-dioxo-isoxazolidinium betaine 
• 58007-35-5 4-(4-chloro-phenyl)-2-(4-methoxy-benzylidene)-3,5-dioxo-isoxazolidinium betaine 
• 58007-37-7 2-benzylidene-4-(4-chloro-phenyl)-3,5-dioxo-isoxazolidinium betaine 
• 131605-41-9 Acetic acid 2-(4-chloro-phenyl)-3-hydroxy-propyl ester 

Relevant articles and documents

Production process of 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol

The invention discloses a production process of 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol. The process comprises the following steps: taking p-chloroiodobenzene and diethyl malonate as initialraw materials; firstly, subjecting the p-chloroiodobenzene and diethyl malonate to coupling reaction to prepare a compound 3; carrying out alkylation reaction on the compound 3 and methyl iodide to obtain a compound 4; reacting the compound 4 with lithium aluminum hydride to obtain a 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol crude product; and finally, subjecting the 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol to a recrystallization procedure, thus obtaining the target product 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol.

Oxidative Coupling of Aryl Boron Reagents with sp3-Carbon Nucleophiles: the Enolate Chan-Evans-Lam Reaction

Reported is a versatile new oxidative method for the arylation of activated methylene species. Under mild reaction conditions (RT to 40 C), Cu(OTf)2 mediates the selective coupling of functionalized aryl boron species with a variety of stabilized sp3-nucl

An efficient method for the preparation of mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC)

An efficient method for the synthesis of mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC) has been described. Using this method many sterically hindered and highly substituted mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate were synthesized in high yield.