19677-37-3

Usage

Uses

Used in Pharmaceutical Industry:
DIETHYL 4-CHLOROPHENYL MALONATE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its role in the production process is crucial for creating a range of medications that can address different health conditions.
Used in Scientific Research:
DIETHYL 4-CHLOROPHENYL MALONATE is employed as a research compound in various scientific studies. Its unique properties make it a valuable tool for understanding chemical reactions and exploring new avenues in drug development and other applications.

Upstream product

• 64-17-5 ethanol 
• 147795-56-0 ethyl 2-(4-chlorophenyl)-2-cyanoacetate 
• 14062-24-9 4-chloro-benzeneacetic acid, ethyl ester 
• 105-58-8 Diethyl carbonate 
• 105-53-3 diethyl malonate 
• 86409-62-3 tricarbonyl(1,4-dichlorobenzene)chromium⁽⁰⁾ 
• 106-39-8 bromochlorobenzene 
• 623-49-4 ethyl cyanoformate 
• 19213-72-0 ethyl 1-imidazolecarboxylate 
• 7519-91-7 tris(4-chlorophenyl)boroxine 
• 140-53-4 p-chlorobenzyl cyanide 
• 1878-66-6 4-chlorophenylacetic Acid 
• 637-87-6 1-Chloro-4-iodobenzene 
• 106-46-7 para-dichlorobenzene 

Downstream Products

• 58007-14-0 4-(4-chloro-phenyl)-isoxazolidine-3,5-dione 
• 106367-56-0 4-(p-methoxyphenyl)-3,5-dihydroxypyrazole 
• 199436-87-8 2-(4-Chloro-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-malonic acid diethyl ester 
• 199437-08-6 2-(4-Chloro-phenyl)-2-(2-cyano-ethyl)-malonic acid diethyl ester 
• 92494-41-2 Cyan-methyl-(4-chlor-phenyl)-malonsaeure-diaethylester 
• 199436-98-1 2-(4-Chloro-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionyl chloride 
• 199436-96-9 N-[2-Carboxy-2-(4-chloro-phenyl)-ethyl]-phthalamic acid 
• 199436-99-2 2-(4-Chloro-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-hydroxy-propionamide 
• 69308-37-8 (R)-baclofen 
• 159248-22-3 Acetic acid (S)-2-(4-chloro-phenyl)-3-hydroxy-propyl ester 
• 159156-89-5 4-azido-3-(p-chlorophenyl)butyronitrile 
• 159156-86-2 4-acetoxy-3-(p-chlorophenyl)butyronitrile 

Relevant academic research and scientific papers

Production process of 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol

The invention discloses a production process of 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol. The process comprises the following steps: taking p-chloroiodobenzene and diethyl malonate as initialraw materials; firstly, subjecting the p-chloroiodobenzene and diethyl malonate to coupling reaction to prepare a compound 3; carrying out alkylation reaction on the compound 3 and methyl iodide to obtain a compound 4; reacting the compound 4 with lithium aluminum hydride to obtain a 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol crude product; and finally, subjecting the 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol to a recrystallization procedure, thus obtaining the target product 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol.

OXIDATIVE COUPLING OF ARYL BORON REAGENTS WITH SP3-CARBON NUCLEOPHILES, AND AMBIENT DECARBOXYLATIVE ARYLATION OF MALONATE HALF-ESTERS VIA OXIDATIVE CATALYSIS

Described herein are methods of oxidative coupling of aryl boron reagents with sp3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis.

Oxidative Coupling of Aryl Boron Reagents with sp3-Carbon Nucleophiles: the Enolate Chan-Evans-Lam Reaction

Reported is a versatile new oxidative method for the arylation of activated methylene species. Under mild reaction conditions (RT to 40 C), Cu(OTf)2 mediates the selective coupling of functionalized aryl boron species with a variety of stabilized sp3-nucl

Oxidative coupling of aryl boron reagents with sp3-carbon nucleophiles: The enolate chan–evans–lam reaction

Reported is a versatile new oxidative method for the arylation of activated methylene species. Under mild reaction conditions (RT to 40°C), Cu(OTf)2mediates the selective coupling of functionalized aryl boron species with a variety of stabilized sp3-nucleophiles. Tertiary malonates and amido esters can be employed as substrates to generate quaternary centers. Complementing either traditional cross-coupling or SNAr protocols, the transformation is chemoselective in the presence of halogen electrophiles, including aryl bromides and iodides. Substrates bearing amide, sulfonyl, and phosphonyl groups, which are not amenable to coupling under mild Hurtley-type conditions, are suitable reaction partners.

3-aryl-6-methoxy-2-oxo-1,2-dihydroquinoline-4-carbonitriles as solvent and pH independent green fluorescent dyes

Highly fluorescent and stable 3-aryl-6-methoxy-2-oxoquinoline-4- carbonitriles 6 (λexc = 408 nm and λem = 510 nm) were synthesized starting from appropriate arylmalonates 2. Ring closure reaction with p-anisidine gave 4-hydroxyquinol

An efficient method for the preparation of mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC)

An efficient method for the synthesis of mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC) has been described. Using this method many sterically hindered and highly substituted mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate were synthesized in high yield.

Synthesis of optically active heterocyclic compounds by preparation of 1,3-dinitro derivatives and enzymatic enantioselective desymmetrization of prochiral diamines

A general approach for the highly efficient chemical preparation of novel optically active 2-substituted propane-1,3-diamines is described. Diamines have been obtained from the corresponding commercially available aldehydes in a straightforward, two-step synthesis via the corresponding 1,3-dinitro compounds, which were hydrogenated under mild reaction conditions by using platinum dioxide as the catalyst. Subsequent enzymatic enantioselective desymmetrization mediated by Pseudomonas cepacia lipase allowed the recovery of a family of monocarbamates in good to high, enantiomeric excesses (70-90% ee).

Process for Preparing 2-Arylcarbonyl Compounds, 2-Aryl Esters and 2-Arylnitriles and their Heteroaromatic Analogues

Process for preparing compounds by cross-coupling of enolizable carbonyl compounds, nitriles or their analogues with substituted aryl or heteroaryl compounds in the presence of a Br?nsted base and of a catalyst or precatalyst containing a.) a transition m

2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY

2,4-Diaminoquinazolines of formulae I-IV and VI (I, II, III, IV and VI) are useful for treating spinal muscular atrophy (SMA).

A general and mild copper-catalyzed arylation of diethyl malonate

Chemical equation presented A general method for the synthesis of α-aryl malonates is described. The coupling of an aryl iodide and diethyl malonate in the presence of Cs2CO3 and catalytic amounts of copper(I) iodide and 2-phenylphenol affords the α-aryl malonate in good to excellent yields. The mild reaction conditions and high levels of functional group compatibility make this an attractive synthetic alternative to previous methods.