124498-15-3

Basic information

• Product Name: 3-BROMO-5-(CHLOROMETHYL)ISOXAZOLE
• Synonyms: 3-BROMO-5-(CHLOROMETHYL)ISOXAZOLE;3-broMo-5-(chloroMethyl)-1,2-oxazole
• CAS NO: 124498-15-3
• Molecular Formula: C4H3BrClNO
• Molecular Weight: 196.43
• Product Categories: Methyl Halides;Oxazoles, Isoxazoles & Benzoxazoles;Methyl Halides;Oxazoles, Isoxazoles & Benzoxazoles
• Mol File: 124498-15-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 277.2 °C at 760 mmHg
• Flash Point: 121.5 °C
• Appearance: /
• Density: 1.796 g/cm³
• Vapor Pressure: 0.00772mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: 3-BROMO-5-(CHLOROMETHYL)ISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-5-(CHLOROMETHYL)ISOXAZOLE(124498-15-3)
• EPA Substance Registry System: 3-BROMO-5-(CHLOROMETHYL)ISOXAZOLE(124498-15-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 124498-15-3(Hazardous Substances Data)

Usage

General Description

3-Bromo-5-(chloromethyl)isoxazole is a synthetic organic compound that comes under the class of isoxazoles which are polar organic compounds containing an isoxazole ring. This specific compound stands out for its bromine and chloromethane substituents. It is associated with potential applications in medicinal chemistry and the synthesis of various pharmaceuticals, as isoxazole derivatives play a significant role in developing therapeutic agents for a variety of diseases. However, as is the case with many synthetic chemicals, it’s necessary to handle it with appropriate safety measures to avoid any health hazards it might present. Detailed information on its properties, such as its molecular weight, boiling point, density, and more, can be found on chemical databases.

InChI:InChI=1/C4H3BrClNO/c5-4-1-3(2-6)8-7-4/h1H,2H2

Upstream product

• 78-88-6 2,3-Dichloroprop-1-ene 
• 74213-24-4 N-dibromomethylidenehydroxylamine 
• 624-65-7 2-propynyl chloride 

Downstream Products

• 2763-93-1 5-Aminomethyl-3-bromoisoxazole 

Relevant articles and documents

An improved synthesis of muscimol

A regiospecific 1,3-dipolar cycloaddition/elimination is the key-step of a convenient, gram-scale synthesis of the GABA-agonist muscimol (1).

Synthesis and pharmacological investigation of cholinergic ligands structurally related to muscarone

Five new analogs of muscarone were synthesized in order to evulate the influence of the carbonyl group on muscarinic activity.We chose to introduce structural variations at the C-2 and C-3 positions of the tetrahydrofuran ring.The muscarinic activity was evaluated in vitro on guinea pig atria and ileum as well as on rat jejunum and urinary bladder.All the new derivatives are less potent than muscarone and three of them displayed a potency very close to that previously reported for muscarine.The tissue selectivity observed for the 3-methylene derivative which is eight times more potent on guinea pig ileum than atria is worth noting.The present data show the lack of a simple relationship between the polarity of the group located in the 3-position of the ring and the muscarinic activity.

PHARMACOLOGICALLY ACTIVE THIOUREA AND UREA COMPOUNDS

The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.