1245-26-7Relevant academic research and scientific papers
Anticholinesterase activity of 4-aminoquinolines related to amodiaquine and their respective N-oxides
Go,Ngiam,Lim
, p. 81 - 85 (2007/10/02)
The inhibitory activities of a series of substituted 4-aminoquinolines related to the antimalarial agent amodiaquine and their respective N-oxides toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) have been determined and discussed in terms of their proposed mode of interaction with the enzyme surface. A marked difference was noted in the AChE and BChE inhibitory potencies of these compounds. The strong anti-AChE activity of amodiaquine has been explained by a specific two-point interaction with the anionic site and acidic group of AChE. However, such an interaction appears to be absent in the case of the amodiaquine inhibition of BChE, suggesting differences in the ability of the enzymes to accommodate similar inhibitory molecules.
