124530-88-7Relevant academic research and scientific papers
N-heterocyclic carbene catalyzed formal [3+2] annulation reaction of enals: An efficient enantioselective access to spiro-heterocycles
Guo, Chang,Schedler, Michael,Daniliuc, Constantin G.,Glorius, Frank
supporting information, p. 10232 - 10236 (2015/03/31)
A highly enantioselective N-heterocyclic carbene (NHC) catalyzed formal [3+2] annulation of α,β-unsaturated aldehydes with azaaurones or aurone generating spiro-heterocycles has been developed. The protocol represents a unique NHC-activation-based approach to access spiro-heterocyclic derivatives bearing a quaternary stereogenic center with high optical purity (up to 95 % ee).
Synthesis and Reactions of 1-Acetyl-2-benzylidene-3-oxo-2,3-dihydroindoles
Buzas, A.,Merour, J. Y.
, p. 458 - 461 (2007/10/02)
1-Acetyl-3-oxo-2,3-dihydroindoles were reacted with substituted benzaldehydes affording 1-acetyl-2-arylmethylene-3-oxo-2,3-dihydroindoles which were selectively reduced by hydrogen; then a Horner-Emmons reaction gave the precursors of 2-substituted trypta
